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    Acap3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313772, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Acap3provided by RGD
    Official Full Name
    ArfGAP with coiled-coil, ankyrin repeat and PH domains 3provided by RGD
    Primary source
    RGD:1310711
    See related
    EnsemblRapid:ENSRNOG00000022307 AllianceGenome:RGD:1310711
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Centb5
    Summary
    Predicted to enable GTPase activator activity. Predicted to act upstream of or within neuron migration and regulation of neuron projection development. Predicted to be located in growth cone. Orthologous to human ACAP3 (ArfGAP with coiled-coil, ankyrin repeat and PH domains 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 101.3), Lung (RPKM 65.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Acap3 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171783382..171797709)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166501150..166515477)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173340060..173354756)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene integrator complex subunit 11 Neighboring gene pseudouridine synthase like 1 Neighboring gene sodium channel epithelial 1 delta subunit Neighboring gene ubiquitin-conjugating enzyme E2, J2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ACAP3, the GTPase-activating protein specific to the small GTPase Arf6, regulates neuronal migration in the developing cerebral cortex. Miura Y, et al. Biochem Biophys Res Commun, 2017 Nov 18. PMID 28919417
    2. ACAP3 regulates neurite outgrowth through its GAP activity specific to Arf6 in mouse hippocampal neurons. Miura Y, et al. Biochem J, 2016 Sep 1. PMID 27330119

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3
    Names
    centaurin, beta 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395748.1 → NP_001382677.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6A5L6, A0A8I6GJX2
      Related
      ENSRNOP00000086578.1, ENSRNOT00000114207.2
      Conserved Domains (5) summary
      PTZ00322
      Location:705 → 800
      PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
      cd07637
      Location:16 → 215
      BAR_ACAP3; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with Coiled-coil, ANK repeat and PH domain containing protein 3
      cd13250
      Location:271 → 367
      PH_ACAP; ArfGAP with coiled-coil, ankyrin repeat and PH domains Pleckstrin homology (PH) domain
      sd00045
      Location:700 → 731
      ANK; ANK repeat [structural motif]
      cd08850
      Location:403 → 518
      ArfGap_ACAP3; ArfGAP domain of ACAP3 (ArfGAP with Coiled-coil, ANK repeat and PH domains 3)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171783382..171797709
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287838.1 → XP_063143908.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5N8, A0A8I6A5L6
      Related
      ENSRNOP00000073498.2, ENSRNOT00000078306.3

    2. XM_063287839.1 → XP_063143909.1  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A5L6
      Related
      ENSRNOP00000061938.2, ENSRNOT00000067841.4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107999.1: Suppressed sequence

      Description
      NM_001107999.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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