Cr1l complement C3b/C4b receptor 1 like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cr1lprovided by RGD
Official Full Name: complement C3b/C4b receptor 1 likeprovided by RGD
Primary source: RGD:2399
See related: EnsemblRapid:ENSRNOG00000008193 AllianceGenome:RGD:2399
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cr1; Crry
Summary: This gene encodes a membrane-bound inhibitor of complement activation, which contains several tandemly arranged short consensus repeats (SCRs) of approximately 60 amino acids. The encoded protein may play a role in tumor immune surveillance, which is unrelated to complement inhibition. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Biased expression in Lung (RPKM 634.4), Thymus (RPKM 461.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q27

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (109138132..109189068, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (106606952..106660442, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (113824886..113872097, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hemopexin Modulates Expression of Complement Regulatory Proteins in Rat Glomeruli.
Title: Hemopexin Modulates Expression of Complement Regulatory Proteins in Rat Glomeruli.
structure of rat CrrY domains 1-4 has been determined in two distinct crystal forms and reveals a 70 degrees bend between domains 3 and 4
Title: Structures of the rat complement regulator CrrY.
X-ray and neutron scattering was performed on recombinant rat Crry containing the first five SCR domains (rCrry) and mouse Crry with five SCR domains conjugated to the Fc fragment of mouse IgG1 (mCrry-Ig)
Title: The extended multidomain solution structures of the complement protein Crry and its chimeric conjugate Crry-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy.
Crry is involved in the LFA-1 dependent proliferation of thymocytes, a phenomenon that has not been recognized so far.
Title: The role of rat Crry, a complement regulatory protein, in proliferation of thymocytes.
Rat Crry on the surface of human tumor cell lines inhibited rat NK-cell-mediated ADCC. Anti-Crry enhanced NK-mediated ADCC in the absence of complement, suggesting a novel function for rat Crry in immune surveillance unrelated to complement inhibition.
Title: Expression of rat complement control protein Crry on tumor cells inhibits rat natural killer cell-mediated cytotoxicity.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in T cell mediated immunity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within complement activation	ISO Inferred from Sequence Orthology more info
involved_in complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
involved_in female pregnancy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of complement activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of complement activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of complement activation, classical pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of complement activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of complement-dependent cytotoxicity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement component receptor 1-like protein

Names: 5I2 antigen; Complement receptor related protein; antigen 5I2; complement component (3b/4b) receptor 1-like; complement receptor type 1; complement regulatory protein Crry; complement regulatory protein Crry-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005265.1 → NP_001005265.1 complement component receptor 1-like protein isoform 3 precursor

See identical proteins and their annotated locations for NP_001005265.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an in-frame segment including two identical exons, as compared to variant 1. The encoded isoform 3 thus lacks an internal segment, which includes two short consensus repeats, as compared to isoform 1.

Source sequence(s)

CB707374, CB775511, D42114

UniProtKB/TrEMBL

A0A8L2UIA6

Conserved Domains (3) summary

cd00033
Location:99 → 157

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

PHA02927
Location:39 → 290

PHA02927; secreted complement-binding protein; Provisional

pfam00084
Location:300 → 352

Sushi; Sushi repeat (SCR repeat)
NM_019301.2 → NP_062174.1 complement component receptor 1-like protein isoform 2 precursor

See identical proteins and their annotated locations for NP_062174.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame exon, which is one of the three identical exons, as compared to variant 1. The encoded isoform 2 thus lacks an internal segment, or a short consensus repeat, as compared to isoform 1.

Source sequence(s)

CB707374, CB775511, D42114, L36532

UniProtKB/Swiss-Prot

Q63135, Q63612

UniProtKB/TrEMBL

A0A8I6AC67

Related

ENSRNOP00000010798.8, ENSRNOT00000010799.8

Conserved Domains (1) summary

PHA02927
Location:39 → 290

PHA02927; secreted complement-binding protein; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

109138132..109189068 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091020.2 → XP_038946948.1 complement component receptor 1-like protein isoform X3

UniProtKB/TrEMBL

A0A0G2K7Y0, A0A8I6AC67

Related

ENSRNOP00000074390.2, ENSRNOT00000079549.3

Conserved Domains (1) summary

PHA02927
Location:39 → 290

PHA02927; secreted complement-binding protein; Provisional
XM_039091021.2 → XP_038946949.1 complement component receptor 1-like protein isoform X5

UniProtKB/TrEMBL

A0A8L2UIA6

Conserved Domains (2) summary

PHA02639
Location:157 → 413

PHA02639; EEV host range protein; Provisional

PHA02927
Location:39 → 290

PHA02927; secreted complement-binding protein; Provisional
XM_063272558.1 → XP_063128628.1 complement component receptor 1-like protein isoform X4

UniProtKB/TrEMBL

A0A8I5ZT27
XM_039091019.2 → XP_038946947.1 complement component receptor 1-like protein isoform X2

UniProtKB/TrEMBL

A0A8I6AC67, A0A8L2R7U2

Related

ENSRNOP00000097736.2, ENSRNOT00000120085.2

Conserved Domains (1) summary

PHA02927
Location:39 → 290

PHA02927; secreted complement-binding protein; Provisional
XM_063272557.1 → XP_063128627.1 complement component receptor 1-like protein isoform X1

UniProtKB/TrEMBL

A0A8I5ZT27

Related

ENSRNOP00000101783.1, ENSRNOT00000165602.1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001005330.1: Suppressed sequence

Description

NM_001005330.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.