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    Grap2 GRB2-related adaptor protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366962, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Grap2provided by RGD
    Official Full Name
    GRB2-related adaptor protein 2provided by RGD
    Primary source
    RGD:1307605
    See related
    EnsemblRapid:ENSRNOG00000018316 AllianceGenome:RGD:1307605
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in several cellular components, including cytosol; endosome; and nucleoplasm. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human GRAP2 (GRB2 related adaptor protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 453.4), Spleen (RPKM 216.3) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Grap2 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (113997356..114071073)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (112117142..112190880)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (121791330..121864835)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene ENTH domain containing 1 Neighboring gene BAF nuclear assembly factor 1, pseudogene 5 Neighboring gene ribosomal protein L22 like 1, pseudogene 3 Neighboring gene family with sequence similarity 83, member F Neighboring gene ribosomal protein L26, pseudogene 1 Neighboring gene trinucleotide repeat containing adaptor 6B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Selective impairment of FcepsilonRI-mediated allergic reaction in Gads-deficient mice. Yamasaki S, et al. Int Immunol, 2008 Oct. PMID 18664516
    2. Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL. Tanase CA. PLoS One, 2010 Dec 15. PMID 21179510, Free PMC Article
    3. Genetic variations in humans associated with differences in the course of hepatitis C. Saito T, et al. Biochem Biophys Res Commun, 2004 Apr 30. PMID 15063762
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125066

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GRB2-related adapter protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034944.1 → NP_001030116.1  GRB2-related adapter protein 2

      See identical proteins and their annotated locations for NP_001030116.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105895
      UniProtKB/TrEMBL
      D3ZG10, Q3KR57
      Related
      ENSRNOP00000094684.1, ENSRNOT00000095205.2
      Conserved Domains (3) summary
      cd09941
      Location:54 → 147
      SH2_Grb2_like; Src homology 2 domain found in Growth factor receptor-bound protein 2 (Grb2) and similar proteins
      cd11950
      Location:271 → 323
      SH3_GRAP2_C; C-terminal Src homology 3 domain of GRB2-related adaptor protein 2
      cl17036
      Location:2 → 53
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      113997356..114071073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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