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    Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361314, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arap3provided by RGD
    Official Full Name
    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3provided by RGD
    Primary source
    RGD:1304938
    See related
    EnsemblRapid:ENSRNOG00000055527 AllianceGenome:RGD:1304938
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Centd3; Arap3-ps1; RGD1304938
    Summary
    Predicted to enable GTPase activator activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in regulation of actin cytoskeleton organization. Predicted to be active in cytoplasm. Orthologous to human ARAP3 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 249.5), Heart (RPKM 99.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Arap3 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (30058739..30085415, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (29806214..29834217, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (31112083..31138142, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene histone deacetylase 3 Neighboring gene FCH and double SH3 domains 1 Neighboring gene RELT-like 2 Neighboring gene uncharacterized LOC134483010 Neighboring gene uncharacterized LOC108348772

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner. I ST, et al. J Cell Sci, 2004 Dec 1. PMID 15546919
    2. Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices. Krugmann S, et al. Mol Cell, 2002 Jan. PMID 11804589
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
    Names
    ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3, pseudogene 1
    centaurin, delta 3
    dual-specificity Rho- and Arf-GTPase activating protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427276.1 → NP_001414205.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A0G2JUX2
      Related
      ENSRNOP00000076387.2, ENSRNOT00000113487.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      30058739..30085415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097402.2 → XP_038953330.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JUX2
      Conserved Domains (8) summary
      cd09490
      Location:4 → 66
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:907 → 1082
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:285 → 377
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:392 → 475
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13259
      Location:1211 → 1327
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      cd17902
      Location:485 → 600
      ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
      cl17171
      Location:672 → 784
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:1114 → 1211
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    2. XM_039097405.2 → XP_038953333.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JUX2
      Related
      ENSRNOP00000107707.1, ENSRNOT00000157872.1
      Conserved Domains (8) summary
      cd09490
      Location:4 → 66
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:907 → 1082
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:285 → 377
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:392 → 475
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13259
      Location:1211 → 1327
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      cd17902
      Location:485 → 600
      ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
      cl17171
      Location:672 → 784
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:1114 → 1211
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. XM_039097404.2 → XP_038953332.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JUX2, A0A0G2JVX3, A6J3E4
      Related
      ENSRNOP00000069654.3, ENSRNOT00000080097.3
      Conserved Domains (8) summary
      cd09490
      Location:4 → 66
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:906 → 1081
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:284 → 376
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:391 → 474
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13259
      Location:1210 → 1326
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      cd17902
      Location:484 → 599
      ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
      cl17171
      Location:671 → 783
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:1113 → 1210
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    4. XM_039097403.2 → XP_038953331.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JUX2
      Related
      ENSRNOP00000069263.3, ENSRNOT00000084438.3
      Conserved Domains (8) summary
      cd09490
      Location:4 → 66
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:907 → 1082
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:285 → 377
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:392 → 475
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd13259
      Location:1211 → 1327
      PH5_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 5
      cd17902
      Location:485 → 600
      ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
      cl17171
      Location:672 → 784
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:1114 → 1211
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    5. XM_063277465.1 → XP_063133535.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JUX2

    6. XM_063277466.1 → XP_063133536.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X4

    7. XM_039097406.2 → XP_038953334.1  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A8I5XUU6, A6J3E5
      Conserved Domains (7) summary
      cd09490
      Location:4 → 66
      SAM_Arap1,2,3; SAM domain of Arap1,2,3 (angiotensin receptor-associated protein)
      cd04385
      Location:907 → 1082
      RhoGAP_ARAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity ...
      cd13253
      Location:285 → 377
      PH1_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 1
      cd13254
      Location:392 → 475
      PH2_ARAP; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain, repeat 2
      cd17902
      Location:485 → 600
      ArfGap_ARAP3; ArfGap with Rho-Gap domain, ANK repeat and PH domain-containing protein 3
      cl17171
      Location:672 → 784
      PH-like; Pleckstrin homology-like domain
      cl28922
      Location:1114 → 1143
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein Strain
    Heading Accession and Version

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