U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Fundc2 FUN14 domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361288, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Fundc2provided by RGD
    Official Full Name
    FUN14 domain containing 2provided by RGD
    Primary source
    RGD:1560916
    See related
    EnsemblRapid:ENSRNOG00000024066 AllianceGenome:RGD:1560916
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560916
    Summary
    Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in autophagy of mitochondrion; intracellular triglyceride homeostasis; and regulation of platelet activation. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Orthologous to human FUNDC2 (FUN14 domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 236.6), Heart (RPKM 113.8) and 9 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Fundc2 in Genome Data Viewer
    Location:
    18p13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (142829..155123, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (128473..138232, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (401878..407954)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene vomeronasal 2 receptor, 75 Neighboring gene BRCA1/BRCA2-containing complex, subunit 3, pseudogene 7 Neighboring gene C-X9-C motif containing 4 Neighboring gene mature T-cell proliferation 1 Neighboring gene uncharacterized LOC134482991 Neighboring gene coagulation factor VIII Neighboring gene myotubularin related protein 1 Neighboring gene uncharacterized LOC134482992

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes. Zhao X, et al. Mol Cell Proteomics, 2011 Jan. PMID 20833797, Free PMC Article
    2. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular triglyceride homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    FUN14 domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135757.1 → NP_001129229.1  FUN14 domain-containing protein 2

      See identical proteins and their annotated locations for NP_001129229.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I6AFI8
      Related
      ENSRNOP00000091610.2, ENSRNOT00000108744.2
      Conserved Domains (1) summary
      pfam04930
      Location:49 → 137
      FUN14; FUN14 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      142829..155123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039096945.2 → XP_038952873.1  FUN14 domain-containing protein 2 isoform X2

      Related
      ENSRNOP00000098724.1, ENSRNOT00000127983.1
      Conserved Domains (1) summary
      pfam04930
      Location:97 → 152
      FUN14; FUN14 family

    2. XM_039096948.2 → XP_038952876.1  FUN14 domain-containing protein 2 isoform X5

      Related
      ENSRNOP00000099877.1, ENSRNOT00000128470.1
      Conserved Domains (1) summary
      pfam04930
      Location:49 → 104
      FUN14; FUN14 family

    3. XM_039096946.1 → XP_038952874.1  FUN14 domain-containing protein 2 isoform X3

      Conserved Domains (1) summary
      pfam04930
      Location:81 → 136
      FUN14; FUN14 family

    4. XM_039096944.1 → XP_038952872.1  FUN14 domain-containing protein 2 isoform X1

      Conserved Domains (1) summary
      pfam04930
      Location:129 → 184
      FUN14; FUN14 family

    5. XM_017600984.3 → XP_017456473.3  FUN14 domain-containing protein 2 isoform X4

      UniProtKB/TrEMBL
      D3ZAQ0
      Related
      ENSRNOP00000036105.4, ENSRNOT00000033618.5

    6. XM_063277458.1 → XP_063133528.1  FUN14 domain-containing protein 2 isoform X7

      Related
      ENSRNOP00000108119.1, ENSRNOT00000133332.1

    7. XM_063277459.1 → XP_063133529.1  FUN14 domain-containing protein 2 isoform X8

    8. XM_039096949.2 → XP_038952877.1  FUN14 domain-containing protein 2 isoform X6

      Conserved Domains (1) summary
      pfam04930
      Location:133 → 188
      FUN14; FUN14 family

    9. XM_063277460.1 → XP_063133530.1  FUN14 domain-containing protein 2 isoform X9

      Related
      ENSRNOP00000101715.1, ENSRNOT00000166370.1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools