Olfm1 olfactomedin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Olfm1provided by RGD
Official Full Name: olfactomedin 1provided by RGD
Primary source: RGD:620320
See related: EnsemblRapid:ENSRNOG00000009862 AllianceGenome:RGD:620320
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Noe1; D2Sut1e
Summary: Involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane. Predicted to be located in several cellular components, including axonal growth cone; neuronal cell body; and synaptic membrane. Predicted to be part of AMPA glutamate receptor complex. Predicted to be active in extracellular space and glutamatergic synapse. Predicted to be extrinsic component of postsynaptic density membrane. Orthologous to human OLFM1 (olfactomedin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 633.7), Lung (RPKM 37.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (31918512..31956261)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (11520522..11558240)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (6761031..6798739)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

Olfm1 (e-PCR), detects polymorphism
- UniSTS:534577

AW742568 (e-PCR)
- UniSTS:207311

D78264 (e-PCR)
- UniSTS:158941

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in atrioventricular valve formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cardiac epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuronal signal transduction	ISO Inferred from Sequence Orthology more info
involved_in neuronal signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in regulation of axon extension	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	EXP Inferred from Experiment more info	PubMed
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in axonal growth cone	ISO Inferred from Sequence Orthology more info
located_in axonal growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extrinsic component of postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of synaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: noelin

Names: 1B426B; neuronal olfactomedin-related ER localized protein; olfactomedin related ER localized protein; pancortin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429602.1 → NP_001416531.1 noelin isoform b precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6JTM7
NM_001429603.1 → NP_001416532.1 noelin isoform c precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6JTM4
NM_001429604.1 → NP_001416533.1 noelin isoform d precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6JTM5
NM_053573.2 → NP_446025.1 noelin isoform a precursor

See identical proteins and their annotated locations for NP_446025.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q62606, Q62607, Q62608, Q62609

UniProtKB/TrEMBL

A6JTM6

Related

ENSRNOP00000013443.3, ENSRNOT00000013443.8

Conserved Domains (3) summary

smart00284
Location:228 → 478

OLF; Olfactomedin-like domains

PRK03918
Location:92 → 218

PRK03918; DNA double-strand break repair ATPase Rad50

pfam12308
Location:56 → 152

Noelin-1; Neurogenesis glycoprotein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

31918512..31956261

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233877.4 → XP_006233939.1 noelin isoform X3

Conserved Domains (1) summary

pfam12308
Location:28 → 124

Noelin-1; Neurogenesis glycoprotein
XM_006233875.4 → XP_006233937.1 noelin isoform X1

Related

ENSRNOP00000077356.1, ENSRNOT00000104931.2

Conserved Domains (3) summary

smart00284
Location:200 → 450

OLF; Olfactomedin-like domains

PRK03918
Location:64 → 190

PRK03918; DNA double-strand break repair ATPase Rad50

pfam12308
Location:28 → 124

Noelin-1; Neurogenesis glycoprotein
XM_006233876.5 → XP_006233938.1 noelin isoform X2

Related

ENSRNOP00000060981.3, ENSRNOT00000065953.4

Conserved Domains (1) summary

pfam12308
Location:56 → 152

Noelin-1; Neurogenesis glycoprotein