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    Pex11a peroxisomal biogenesis factor 11 alpha [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85249, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pex11aprovided by RGD
    Official Full Name
    peroxisomal biogenesis factor 11 alphaprovided by RGD
    Primary source
    RGD:619842
    See related
    EnsemblRapid:ENSRNOG00000015003 AllianceGenome:RGD:619842
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pmp26p
    Summary
    Predicted to enable protein homodimerization activity. Involved in peroxisome membrane biogenesis. Located in peroxisomal membrane. Orthologous to human PEX11A (peroxisomal biogenesis factor 11 alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 59.0), Liver (RPKM 33.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pex11a in Genome Data Viewer
    Location:
    1q31
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (143089410..143096491, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (133680091..133687172, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (141474189..141481270, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 7 Neighboring gene uncharacterized LOC120099868 Neighboring gene perilipin 1 Neighboring gene WD repeat domain 93 Neighboring gene small nuclear ribonucleoprotein polypeptide E like 2 Neighboring gene mesoderm posterior bHLH transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Clofibrate-inducible, 28-kDa peroxisomal integral membrane protein is encoded by PEX11. Abe I, et al. FEBS Lett, 1998 Jul 24. PMID 9714566
    2. Peroxisome biogenesis: involvement of ARF and coatomer. Passreiter M, et al. J Cell Biol, 1998 Apr 20. PMID 9548716, Free PMC Article
    3. The peroxisomal membrane protein import receptor Pex3p is directly transported to peroxisomes by a novel Pex19p- and Pex16p-dependent pathway. Matsuzaki T, et al. J Cell Biol, 2008 Dec 29. PMID 19114594, Free PMC Article
    4. Targeting of hFis1 to peroxisomes is mediated by Pex19p. Delille HK, et al. J Biol Chem, 2008 Nov 7. PMID 18782765, Free PMC Article
    5. Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli. Schrader M, et al. J Biol Chem, 1998 Nov 6. PMID 9792670

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peroxisome fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome membrane biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peroxisome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of peroxisome size ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal membrane protein 11A
    Names
    28 kDa peroxisomal integral membrane protein
    PEX11-alpha
    PEX11alpha
    PMP28
    peroxin-11A
    peroxisomal biogenesis factor 11A
    peroxisomal coatomer receptor
    peroxisomal membrane protein 26
    peroxisomal membrane protein Pmp26p (Peroxin-11)
    pex11palpha
    protein PEX11 homolog alpha
    rnPEX11p

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053487.2 → NP_445939.1  peroxisomal membrane protein 11A

      See identical proteins and their annotated locations for NP_445939.1

      Status: VALIDATED

      Source sequence(s)
      AJ224120, BC061835, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      O70597, Q6P749
      UniProtKB/TrEMBL
      A6JC69
      Related
      ENSRNOP00000020229.4, ENSRNOT00000020229.8
      Conserved Domains (1) summary
      pfam05648
      Location:1 → 237
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      143089410..143096491 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092913.2 → XP_038948841.1  peroxisomal membrane protein 11A isoform X1

      Conserved Domains (1) summary
      pfam05648
      Location:2 → 117
      PEX11; Peroxisomal biogenesis factor 11 (PEX11)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70597.1 GenPept UniProtKB/Swiss-Prot:O70597

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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