Nr5a2 nuclear receptor subfamily 5, group A, member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nr5a2provided by RGD
Official Full Name: nuclear receptor subfamily 5, group A, member 2provided by RGD
Primary source: RGD:68353
See related: EnsemblRapid:ENSRNOG00000000653 AllianceGenome:RGD:68353
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ftf; Lrh-1
Summary: Enables double-stranded DNA binding activity and nuclear receptor activity. Involved in calcineurin-mediated signaling. Predicted to be located in cytoplasm and nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Orthologous to human NR5A2 (nuclear receptor subfamily 5 group A member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 147.4), Lung (RPKM 14.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (50865253..50985107, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (48313634..48433494, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (53750470..53870288, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TGF-beta1 induced activations of Smad2 and miRNAs inhibit SF-1- and LRH-1-dependent CYP19 expression in rat Leydig cellsdagger.
Title: TGF-β1 induced activations of Smad2 and miRNAs inhibit SF-1- and LRH-1-dependent CYP19 expression in rat Leydig cells†.
Testosterone, but not dihydrotestosterone, stimulates aryl hydrocarbon receptor expression and the interaction between aryl hydrocarbon receptor and androgen receptor, leading to the stimulation of Lrh-1 expression.
Title: Testosterone-dependent interaction between androgen receptor and aryl hydrocarbon receptor induces liver receptor homolog 1 expression in rat granulosa cells.
demonstrated that the androgen receptor binds to an androgen response element located within the LRH-1 promoter
Title: Testosterone, not 5α-dihydrotestosterone, stimulates LRH-1 leading to FSH-independent expression of Cyp19 and P450scc in granulosa cells.
These data provide evidence that LRH-1 plays an important role in the regulation of testicular aromatase expression, and implicate LRH-1 as a regulator of rat spermatogenesis, in which estrogens are emerging as important mediators.
Title: Localization and regulation of aromatase liver receptor homologue-1 in the developing rat testis.
cAMP signaling could change the dynamic process of sumoylation and repress LRH-1 targeting to nuclear speckles in rat granulosa cells
Title: Liver receptor homolog-1 localization in the nuclear body is regulated by sumoylation and cAMP signaling in rat granulosa cells.
Regulation of pituitary Nr5a2, Inhba, and Inhbb transcripts was limited to young animals.
Title: Anterior pituitary gene expression with reproductive aging in the female rat.
Heat-induced LRH-1 expression in the Sertoli cells may be regulated via ERK1/2 activation pathway.
Title: Heat treatment induces liver receptor homolog-1 expression in monkey and rat sertoli cells.
Regulates the gonadotrope population of the anterior pituitary gland.
Title: Liver receptor homologue-1 regulates gonadotrope function.
evidence provided that LRH-1 plays an important role in the regulation of aromatase expression in Leydig cells
Title: Differential expression of steroidogenic factor-1/adrenal 4 binding protein and liver receptor homolog-1 (LRH-1)/fetoprotein transcription factor in the rat testis: LRH-1 as a potential regulator of testicular aromatase expression.
data indicate that granulosa cells of small and preovulatory follicles express both SF-1 and FTF/LRH-1 and that each orphan receptor may regulate target gene expression in these cells
Title: Differential expression of steroidogenic factor-1 and FTF/LRH-1 in the rodent ovary.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

RH143570 (e-PCR)
- UniSTS:232816

D13Rat154 (e-PCR), detects polymorphism
- UniSTS:226530

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acinar cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bile acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in calcineurin-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pancreas morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear receptor subfamily 5 group A member 2

Names: FTZ-F1 beta; FTZ-F1 beta2 protein; fetoprotein transcription factor; liver receptor homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021742.1 → NP_068510.1 nuclear receptor subfamily 5 group A member 2

See identical proteins and their annotated locations for NP_068510.1

Status: PROVISIONAL

Source sequence(s)

AB012960

UniProtKB/Swiss-Prot

Q9QWM0, Q9QWM1

Related

ENSRNOP00000000812.5, ENSRNOT00000000812.7

Conserved Domains (2) summary

cd07069
Location:320 → 560

NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,

cd07167
Location:107 → 199

NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

50865253..50985107 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006249928.5 → XP_006249990.1 nuclear receptor subfamily 5 group A member 2 isoform X1

See identical proteins and their annotated locations for XP_006249990.1

UniProtKB/TrEMBL

A6ICJ5

Related

ENSRNOP00000096873.1, ENSRNOT00000097279.2

Conserved Domains (2) summary

cd07069
Location:299 → 539

NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,

cd07167
Location:86 → 178

NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
XM_006249929.5 → XP_006249991.1 nuclear receptor subfamily 5 group A member 2 isoform X2

Conserved Domains (2) summary

cd07069
Location:227 → 467

NR_LBD_Lrh-1; The ligand binding domain of the liver receptor homolog-1, a member of nuclear receptor superfamily,

cd07167
Location:14 → 106

NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers