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    Cep350 centrosomal protein 350 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246304, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cep350provided by RGD
    Official Full Name
    centrosomal protein 350provided by RGD
    Primary source
    RGD:621162
    See related
    EnsemblRapid:ENSRNOG00000003882 AllianceGenome:RGD:621162
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cap350
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in microtubule anchoring. Predicted to act upstream of or within non-motile cilium assembly and protein localization to centrosome. Predicted to be active in centriole and centrosome. Orthologous to human CEP350 (centrosomal protein 350). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 141.1), Kidney (RPKM 137.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep350 in Genome Data Viewer
    Location:
    13q21-q22
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (70573597..70714673, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (68023327..68164478, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (73499715..73637707, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L37-like Neighboring gene LIM homeobox 4 Neighboring gene quiescin sulfhydryl oxidase 1 Neighboring gene uncharacterized LOC120096287 Neighboring gene interferon induced transmembrane protein 2, pseudogene 2 Neighboring gene torsin 1A interacting protein 1 Neighboring gene torsin 1A interacting protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. EB1 is required for primary cilia assembly in fibroblasts. Schrøder JM, et al. Curr Biol, 2007 Jul 3. PMID 17600711
    2. The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base. Kanie T, et al. Dev Cell, 2017 Jul 10. PMID 28625565, Free PMC Article
    3. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule anchoring IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within non-motile cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosome-associated protein 350
    Names
    centrosomal protein 350kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427193.1 → NP_001414122.1  centrosome-associated protein 350

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      F1LPD3
      Related
      ENSRNOP00000103622.1, ENSRNOT00000121812.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      70573597..70714673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091366.2 → XP_038947294.1  centrosome-associated protein 350 isoform X2

      UniProtKB/TrEMBL
      F1LPD3
      Related
      ENSRNOP00000005195.10, ENSRNOT00000005195.10
      Conserved Domains (4) summary
      COG5022
      Location:2089 → 2440
      COG5022; Myosin heavy chain [General function prediction only]
      PRK12704
      Location:1675 → 1777
      PRK12704; phosphodiesterase; Provisional
      PTZ00108
      Location:1884 → 2147
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam01302
      Location:2524 → 2588
      CAP_GLY; CAP-Gly domain

    2. XM_039091367.2 → XP_038947295.1  centrosome-associated protein 350 isoform X3

      UniProtKB/TrEMBL
      A0A1W2Q628, F1LPD3
      Related
      ENSRNOP00000076113.2, ENSRNOT00000093655.3
      Conserved Domains (2) summary
      PTZ00121
      Location:1683 → 2289
      PTZ00121; MAEBL; Provisional
      pfam01302
      Location:2484 → 2548
      CAP_GLY; CAP-Gly domain

    3. XM_039091365.2 → XP_038947293.1  centrosome-associated protein 350 isoform X1

      UniProtKB/TrEMBL
      D3ZCA4, F1LPD3
      Conserved Domains (4) summary
      COG5022
      Location:2090 → 2441
      COG5022; Myosin heavy chain [General function prediction only]
      PRK12704
      Location:1676 → 1778
      PRK12704; phosphodiesterase; Provisional
      PTZ00108
      Location:1885 → 2148
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam01302
      Location:2525 → 2589
      CAP_GLY; CAP-Gly domain
    Nucleotide Protein Strain
    Heading Accession and Version

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