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    Nrk Nik related kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315907, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nrkprovided by RGD
    Official Full Name
    Nik related kinaseprovided by RGD
    Primary source
    RGD:1566163
    See related
    EnsemblRapid:ENSRNOG00000008880 AllianceGenome:RGD:1566163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566163
    Summary
    Predicted to enable protein kinase activity. Predicted to be involved in positive regulation of JNK cascade. Predicted to act upstream of or within negative regulation of cell population proliferation; parturition; and regulation of spongiotrophoblast cell proliferation. Predicted to be active in cytosol. Orthologous to human NRK (Nik related kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 34.9), Muscle (RPKM 34.5) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nrk in Genome Data Viewer
    Location:
    Xq32
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (107159154..107256417)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (102365765..102462957)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (109940439..110036361) , (110065199..110089124)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor accessory protein-like 2 Neighboring gene zinc finger CCCH domain-containing protein 14-like Neighboring gene large ribosomal subunit protein eL18-like Neighboring gene UBX domain protein 2A, pseudogene 1 Neighboring gene ATP binding cassette subfamily E member 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NESK, a member of the germinal center kinase family that activates the c-Jun N-terminal kinase pathway and is expressed during the late stages of embryogenesis. Nakano K, et al. J Biol Chem, 2000 Jul 7. PMID 10801798
    2. Nrk, an X-linked protein kinase in the germinal center kinase family, is required for placental development and fetoplacental induction of labor. Denda K, et al. J Biol Chem, 2011 Aug 19. PMID 21715335, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within parturition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of spongiotrophoblast cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nik-related protein kinase
    NP_001178726.1
    NP_001398520.1
    XP_063136078.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191797.1 → NP_001178726.1  nik-related protein kinase isoform 2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      F1LZB6
      Related
      ENSRNOP00000053882.3, ENSRNOT00000057049.5
      Conserved Domains (4) summary
      smart00220
      Location:25 → 296
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      PRK10927
      Location:458 → 638
      PRK10927; essential cell division protein FtsN; Provisional
      cl02434
      Location:1141 → 1421
      CNH; CNH domain
      cl21453
      Location:14 → 296
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001411591.1 → NP_001398520.1  nik-related protein kinase isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      Related
      ENSRNOP00000099115.1, ENSRNOT00000165919.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      107159154..107256417
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063280008.1 → XP_063136078.1  nik-related protein kinase isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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