Prnd prion like protein doppel [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prndprovided by RGD
Official Full Name: prion like protein doppelprovided by RGD
Primary source: RGD:1306618
See related: EnsemblRapid:ENSRNOG00000021260 AllianceGenome:RGD:1306618
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable copper ion binding activity. Predicted to be involved in acrosome reaction and intracellular copper ion homeostasis. Predicted to be located in external side of plasma membrane. Orthologous to human PRND (prion like protein doppel). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 76.8), Muscle (RPKM 31.9) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3q36

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (139666383..139671647)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (119213462..119218742)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (124543227..124548548)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Doppel is expressed early during ontogenesis, and is found in both germ cells and Sertoli cells. Doppel may play a physiological role in acrosome biogenesis.
Title: Spatio-developmental distribution of the prion-like protein doppel in Mammalian testis: a comparative analysis focusing on its presence in the acrosome of spermatids.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables copper ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acrosome reaction	ISO Inferred from Sequence Orthology more info
involved_in intracellular copper ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular copper ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in single fertilization	ISO Inferred from Sequence Orthology more info
NOT involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prion-like protein doppel

Names: prion protein 2 (dublet); prion protein dublet; prion protein-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001102431.3 → NP_001095901.1 prion-like protein doppel isoform 1 precursor

See identical proteins and their annotated locations for NP_001095901.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6A8S4, A7U7N4, C7E3P6

Related

ENSRNOP00000111761.1, ENSRNOT00000154030.1

Conserved Domains (2) summary

pfam00377
Location:63 → 177

Prion; Prion/Doppel alpha-helical domain

pfam11466
Location:1 → 30

Doppel; Prion-like protein Doppel
NM_001415154.3 → NP_001402083.1 prion-like protein doppel isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6A8S4, A7U7N4, C7E3P6

Related

ENSRNOP00000099329.1, ENSRNOT00000164691.1
NM_001429637.1 → NP_001416566.1 prion-like protein doppel isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6HQF0, C7E3P6
NM_001429638.1 → NP_001416567.1 prion-like protein doppel isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6HQF0, C7E3P6