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    Scara5 scavenger receptor class A, member 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305974, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Scara5provided by RGD
    Official Full Name
    scavenger receptor class A, member 5provided by RGD
    Primary source
    RGD:1306539
    See related
    EnsemblRapid:ENSRNOG00000014398 AllianceGenome:RGD:1306539
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306539
    Summary
    Predicted to enable ferritin receptor activity. Predicted to be involved in several processes, including intracellular iron ion homeostasis; iron ion transmembrane transport; and protein homotrimerization. Predicted to act upstream of or within cellular response to heat. Predicted to be located in cell surface and plasma membrane. Orthologous to human SCARA5 (scavenger receptor class A member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 74.3), Heart (RPKM 65.0) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Scara5 in Genome Data Viewer
    Location:
    15p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (44055576..44160593)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (39880017..39985007)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (49069142..49177159)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene nuclear GTPase, germinal center associated Neighboring gene uncharacterized LOC120097185 Neighboring gene uncharacterized LOC108352941 Neighboring gene uncharacterized LOC134482136 Neighboring gene PDZ binding kinase Neighboring gene establishment of sister chromatid cohesion N-acetyltransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of murine SCARA5, a novel class A scavenger receptor that is expressed by populations of epithelial cells. Jiang Y, et al. J Biol Chem, 2006 Apr 28. PMID 16407294
    2. Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Li JY, et al. Dev Cell, 2009 Jan. PMID 19154717, Free PMC Article
    3. Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels. Antoni G, et al. BMC Med Genet, 2011 Aug 2. PMID 21810271, Free PMC Article
    4. Analysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouse lenses. Fujimoto M, et al. J Biol Chem, 2008 Oct 31. PMID 18755693, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ferritin receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in iron ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homotrimerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    scavenger receptor class A member 5
    Names
    scavenger receptor class A, member 5 (putative)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135855.2 → NP_001129327.1  scavenger receptor class A member 5 isoform 2

      See identical proteins and their annotated locations for NP_001129327.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6K6K2
      Conserved Domains (3) summary
      pfam01391
      Location:307 → 374
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:390 → 490
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:395 → 490
      SRCR; Scavenger receptor cysteine-rich domain

    2. NM_001431432.1 → NP_001418361.1  scavenger receptor class A member 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      D3Z926, D4A213

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      44055576..44160593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006252204.4 → XP_006252266.1  scavenger receptor class A member 5 isoform X1

      Related
      ENSRNOP00000019487.5, ENSRNOT00000019487.7
      Conserved Domains (3) summary
      pfam01391
      Location:307 → 374
      Collagen; Collagen triple helix repeat (20 copies)
      smart00202
      Location:391 → 491
      SR; Scavenger receptor Cys-rich
      pfam00530
      Location:396 → 491
      SRCR; Scavenger receptor cysteine-rich domain
    Nucleotide Protein Strain
    Heading Accession and Version

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