Ect2 epithelial cell transforming 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ect2provided by RGD
Official Full Name: epithelial cell transforming 2provided by RGD
Primary source: RGD:1308524
See related: EnsemblRapid:ENSRNOG00000024365 AllianceGenome:RGD:1308524
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTPase regulator activity; protein homodimerization activity; and small GTPase binding activity. Predicted to be involved in several processes, including activation of GTPase activity; bicellular tight junction assembly; and regulation of cell cycle process. Predicted to act upstream of or within cell morphogenesis. Predicted to be located in several cellular components, including bicellular tight junction; cleavage furrow; and midbody. Predicted to be part of centralspindlin complex. Predicted to be active in cell cortex and nucleus. Orthologous to human ECT2 (epithelial cell transforming 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 141.4), Spleen (RPKM 98.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q24

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (111904522..111966786, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (109975813..110037911, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (112769385..112831476, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We thus conclude that Ect2 is involved in annexin V-induced rat Leydig cell proliferation through the RhoA/ROCK pathway
Title: Annexin V-induced rat Leydig cell proliferation involves Ect2 via RhoA/ROCK signaling pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

RH140767 (e-PCR)
- UniSTS:222833

AU049848 (e-PCR)
- UniSTS:146294

BE117772 (e-PCR)
- UniSTS:248718

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cytokinetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis, actomyosin contractile ring assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
part_of centralspindlin complex	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein ECT2

Names: ect2 oncogene; epithelial cell transforming sequence 2 oncogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108547.3 → NP_001102017.2 protein ECT2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I6GJ38, D3ZUD0

Related

ENSRNOP00000018055.7, ENSRNOT00000018055.10

Conserved Domains (4) summary

cd01229
Location:631 → 804

PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain

pfam00533
Location:266 → 341

BRCT; BRCA1 C Terminus (BRCT) domain

pfam00621
Location:456 → 640

RhoGEF; RhoGEF domain

pfam12738
Location:179 → 242

PTCB-BRCT; twin BRCT domain