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    Zbtb6 zinc finger and BTB domain containing 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366029, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zbtb6provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 6provided by RGD
    Primary source
    RGD:1306007
    See related
    EnsemblRapid:ENSRNOG00000009340 AllianceGenome:RGD:1306007
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfp482; Znf482
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in mitochondrion. Predicted to be active in nucleoplasm. Orthologous to human ZBTB6 (zinc finger and BTB domain containing 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 104.9), Brain (RPKM 87.7) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Zbtb6 in Genome Data Viewer
    Location:
    3q11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (41600488..41603902, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (21189160..21207561, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (21679181..21697532, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene NME/NM23 nucleoside diphosphate kinase 2, pseudogene 2 Neighboring gene phosducin like Neighboring gene ring finger and CCCH-type domains 2 Neighboring gene small nucleolar RNA, C/D box 90 Neighboring gene uncharacterized LOC108350365 Neighboring gene zinc finger and BTB domain containing 6 like 1 Neighboring gene zinc finger and BTB domain containing 26 Neighboring gene RAB GTPase activating protein 1 Neighboring gene G protein-coupled receptor 21

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 6
    Names
    zinc finger protein 482

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108953.1NP_001102423.1  zinc finger and BTB domain-containing protein 6

      See identical proteins and their annotated locations for NP_001102423.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473983
      UniProtKB/TrEMBL
      A6JET1, D3ZBL2
      Related
      ENSRNOP00000012364.2, ENSRNOT00000012364.7
      Conserved Domains (5) summary
      COG5048
      Location:251398
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:327347
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18197
      Location:8123
      BTB_POZ_ZBTB6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6)
      pfam00096
      Location:325347
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:339363
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      41600488..41603902 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)