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    Suv39h2 SUV39H2 histone lysine methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364785, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Suv39h2provided by RGD
    Official Full Name
    SUV39H2 histone lysine methyltransferaseprovided by RGD
    Primary source
    RGD:1306969
    See related
    EnsemblRapid:ENSRNOG00000015585 AllianceGenome:RGD:1306969
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including cation binding activity; histone H3K9me2 methyltransferase activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in circadian rhythm; male meiotic nuclear division; and regulation of gene expression. Predicted to act upstream of or within cellular response to hypoxia; chromatin remodeling; and negative regulation of transcription by RNA polymerase II. Predicted to be located in heterochromatin. Predicted to be active in nucleus. Orthologous to human SUV39H2 (SUV39H2 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 55.2), Testes (RPKM 30.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Suv39h2 in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (79665467..79684492)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (74756290..74775332)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (78762897..78782016)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482747 Neighboring gene cerebral dopamine neurotrophic factor Neighboring gene Myb/SANT DNA binding domain containing 7 Neighboring gene heat shock protein family A (Hsp70) member 14 Neighboring gene uncharacterized LOC120097881 Neighboring gene DNA cross-link repair 1C Neighboring gene metallothionein 1, pseudogene 3 Neighboring gene meiosis/spermiogenesis associated 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization. Jack AP, et al. PLoS One, 2013. PMID 23451023, Free PMC Article
    2. Targeting protein lysine methylation and demethylation in cancers. He Y, et al. Acta Biochim Biophys Sin (Shanghai), 2012 Jan. PMID 22194015, Free PMC Article
    3. Structural biology of human H3K9 methyltransferases. Wu H, et al. PLoS One, 2010 Jan 11. PMID 20084102, Free PMC Article
    4. Differential subnuclear localization and replication timing of histone H3 lysine 9 methylation states. Wu R, et al. Mol Biol Cell, 2005 Jun. PMID 15788566, Free PMC Article
    5. Isolation and characterization of Suv39h2, a second histone H3 methyltransferase gene that displays testis-specific expression. O'Carroll D, et al. Mol Cell Biol, 2000 Dec. PMID 11094092, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables S-adenosyl-L-methionine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3K9 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K9 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3K9 trimethyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9me2 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription cis-regulatory region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epigenetic programming in the zygotic pronuclei ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in male meiotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase SUV39H2
    Names
    suppressor of variegation 3-9 homolog 2
    NP_001102353.1
    XP_038951911.1
    XP_063132746.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108883.1 → NP_001102353.1  histone-lysine N-methyltransferase SUV39H2

      See identical proteins and their annotated locations for NP_001102353.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473990
      UniProtKB/TrEMBL
      A6JM14, D3ZIH5
      Related
      ENSRNOP00000020924.3, ENSRNOT00000020924.6
      Conserved Domains (4) summary
      smart00317
      Location:321 → 450
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:236 → 481
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      pfam00385
      Location:119 → 164
      Chromo; Chromo (CHRromatin Organization MOdifier) domain
      pfam05033
      Location:225 → 313
      Pre-SET; Pre-SET motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      79665467..79684492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095983.2 → XP_038951911.1  histone-lysine N-methyltransferase SUV39H2 isoform X1

      Related
      ENSRNOP00000106598.1, ENSRNOT00000144553.1
      Conserved Domains (2) summary
      cd18639
      Location:148 → 196
      CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
      cd10532
      Location:268 → 510
      SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins

    2. XM_063276676.1 → XP_063132746.1  histone-lysine N-methyltransferase SUV39H2 isoform X2

      Related
      ENSRNOP00000104997.1, ENSRNOT00000147697.1
    Nucleotide Protein Strain
    Heading Accession and Version

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