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    Hs6st2 heparan sulfate 6-O-sulfotransferase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302489, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hs6st2provided by RGD
    Official Full Name
    heparan sulfate 6-O-sulfotransferase 2provided by RGD
    Primary source
    RGD:1564397
    See related
    EnsemblRapid:ENSRNOG00000030880 AllianceGenome:RGD:1564397
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563872; RGD1564397
    Summary
    Predicted to enable heparan sulfate 6-O-sulfotransferase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in Paganini-Miozzo syndrome. Orthologous to human HS6ST2 (heparan sulfate 6-O-sulfotransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 149.9), Brain (RPKM 63.2) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hs6st2 in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (135887224..136182388, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (130966547..131261629, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (138675326..138972774, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene high mobility group protein B4-like Neighboring gene mitochondrial ribosomal protein L30, pseudogene 3 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 3, pseudogene 1 Neighboring gene ubiquitin specific peptidase 26 Neighboring gene MAGE family member A14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. Habuchi H, et al. J Biol Chem, 2000 Jan 28. PMID 10644753
    2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heparan sulfate 6-O-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparan sulfate 6-O-sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heparan-sulfate 6-O-sulfotransferase 2
    NP_001178655.1
    XP_006257640.1
    XP_017457459.1
    XP_017457460.1
    XP_017457461.1
    XP_017457462.1
    XP_063135974.1
    XP_063135975.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191726.1 → NP_001178655.1  heparan-sulfate 6-O-sulfotransferase 2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6JMT6, D3ZEK5
      Related
      ENSRNOP00000043184.4, ENSRNOT00000040165.6
      Conserved Domains (1) summary
      pfam03567
      Location:225 → 530
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      135887224..136182388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601970.3 → XP_017457459.1  heparan-sulfate 6-O-sulfotransferase 2 isoform X1

      UniProtKB/TrEMBL
      A6JMT6
      Related
      ENSRNOP00000103693.1, ENSRNOT00000157289.1

    2. XM_017601971.3 → XP_017457460.1  heparan-sulfate 6-O-sulfotransferase 2 isoform X2

      UniProtKB/TrEMBL
      A6JMT5

    3. XM_006257578.5 → XP_006257640.1  heparan-sulfate 6-O-sulfotransferase 2 isoform X3

      UniProtKB/TrEMBL
      A6JMT5
      Related
      ENSRNOP00000109728.1, ENSRNOT00000172807.1
      Conserved Domains (1) summary
      pfam03567
      Location:225 → 490
      Sulfotransfer_2; Sulfotransferase family

    4. XM_017601972.3 → XP_017457461.1  heparan-sulfate 6-O-sulfotransferase 2 isoform X4

      UniProtKB/TrEMBL
      A6JMT6

    5. XM_063279904.1 → XP_063135974.1  heparan-sulfate 6-O-sulfotransferase 2 isoform X6

      UniProtKB/TrEMBL
      A6JMT5

    6. XM_063279905.1 → XP_063135975.1  heparan-sulfate 6-O-sulfotransferase 2 isoform X7

      UniProtKB/TrEMBL
      A6JMT5

    7. XM_017601973.3 → XP_017457462.1  heparan-sulfate 6-O-sulfotransferase 2 isoform X5

      UniProtKB/TrEMBL
      A6JMT6
    Nucleotide Protein Strain
    Heading Accession and Version

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