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    Cttnbp2nl CTTNBP2 N-terminal like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310760, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cttnbp2nlprovided by RGD
    Official Full Name
    CTTNBP2 N-terminal likeprovided by RGD
    Primary source
    RGD:1310822
    See related
    EnsemblRapid:ENSRNOG00000014479 AllianceGenome:RGD:1310822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310822
    Summary
    Predicted to enable protein phosphatase 2A binding activity. Predicted to be involved in protein localization to actin cytoskeleton. Predicted to act upstream of or within negative regulation of transmembrane transport; negative regulation of transporter activity; and protein dephosphorylation. Predicted to be part of FAR/SIN/STRIPAK complex. Predicted to be active in actin cytoskeleton. Orthologous to human CTTNBP2NL (CTTNBP2 N-terminal like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 153.6), Kidney (RPKM 103.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cttnbp2nl in Genome Data Viewer
    Location:
    2q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (195196318..195244792, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (192507963..192554548, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (207495056..207541808, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene Wnt family member 2B Neighboring gene small ribosomal subunit protein eS6-like Neighboring gene uncharacterized LOC134485665 Neighboring gene uncharacterized LOC102548297 Neighboring gene ribosomal protein S23, pseudogene 7 Neighboring gene uncharacterized LOC102548357

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genetic variants related to gap junctions and hormone secretion influence conception rates in cows. Sugimoto M, et al. Proc Natl Acad Sci U S A, 2013 Nov 26. PMID 24218568, Free PMC Article
    2. Identification and analysis of plasticity-induced late-response genes. Hong SJ, et al. Proc Natl Acad Sci U S A, 2004 Feb 17. PMID 14766980, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CTTNBP2 N-terminal-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107712.2 → NP_001101182.2  CTTNBP2 N-terminal-like protein

      See identical proteins and their annotated locations for NP_001101182.2

      Status: VALIDATED

      Source sequence(s)
      CB724536, JAXUCZ010000002
      UniProtKB/TrEMBL
      A6K3Q4, A6K3Q5, D4A8X8
      Related
      ENSRNOP00000019680.4, ENSRNOT00000019680.7
      Conserved Domains (2) summary
      TIGR02168
      Location:100 → 287
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09727
      Location:5 → 188
      CortBP2; Cortactin-binding protein-2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      195196318..195244792 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281915.1 → XP_063137985.1  CTTNBP2 N-terminal-like protein isoform X1

      UniProtKB/TrEMBL
      A6K3Q4, A6K3Q5, D4A8X8

    2. XM_063281913.1 → XP_063137983.1  CTTNBP2 N-terminal-like protein isoform X1

      UniProtKB/TrEMBL
      A6K3Q4, A6K3Q5, D4A8X8

    3. XM_063281914.1 → XP_063137984.1  CTTNBP2 N-terminal-like protein isoform X1

      UniProtKB/TrEMBL
      A6K3Q4, A6K3Q5, D4A8X8
    Nucleotide Protein Strain
    Heading Accession and Version

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