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    Rab22a RAB22A, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366265, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rab22aprovided by RGD
    Official Full Name
    RAB22A, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:1311959
    See related
    EnsemblRapid:ENSRNOG00000005762 AllianceGenome:RGD:1311959
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in several processes, including endosome organization; intracellular protein transport; and regulation of vesicle size. Predicted to be located in actin cytoskeleton; phagocytic vesicle; and plasma membrane. Predicted to be active in early endosome. Orthologous to human RAB22A (RAB22A, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 36.2), Kidney (RPKM 34.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rab22a in Genome Data Viewer
    Location:
    3q42
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (182877746..182924400)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (162459727..162506129)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (171743884..171790558)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E, pseudogene 9 Neighboring gene uncharacterized LOC134486505 Neighboring gene VAMP associated protein B and C Neighboring gene APC down-regulated 1 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human liver cell trafficking mutants: characterization and whole exome sequencing. Yuan F, et al. PLoS One, 2014. PMID 24466322, Free PMC Article
    2. The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking. Kauppi M, et al. J Cell Sci, 2002 Mar 1. PMID 11870209
    3. Rin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22. Woller B, et al. Biochim Biophys Acta, 2011 Jun. PMID 21419809, Free PMC Article
    4. Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. Eathiraj S, et al. Nature, 2005 Jul 21. PMID 16034420, Free PMC Article
    5. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. Seto S, et al. Traffic, 2011 Apr. PMID 21255211

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of vesicle size ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-22A
    NP_001385874.1
    XP_063140363.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398945.1 → NP_001385874.1  ras-related protein Rab-22A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K3Z3, A0A9K3Y893, A6KL10, B0BN19, D4A9H0
      Related
      ENSRNOP00000106765.1, ENSRNOT00000129296.1
      Conserved Domains (1) summary
      cd01860
      Location:5 → 167
      Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      182877746..182924400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063284293.1 → XP_063140363.1  ras-related protein Rab-22A isoform X1

      UniProtKB/TrEMBL
      A0A8I6AES5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108966.1: Suppressed sequence

      Description
      NM_001108966.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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