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    Cdk10 cyclin-dependent kinase 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361434, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdk10provided by RGD
    Official Full Name
    cyclin-dependent kinase 10provided by RGD
    Primary source
    RGD:1304851
    See related
    EnsemblRapid:ENSRNOG00000016088 AllianceGenome:RGD:1304851
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. The human ortholog has been shown to play a role in cellular proliferation. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in Kidney (RPKM 137.7), Adrenal (RPKM 136.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdk10 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (68168040..68184923)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (51260012..51273009)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (56024903..56032610)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene charged multivesicular body protein 1A Neighboring gene spermatogenesis associated 33 Neighboring gene spermatogenesis associated 2-like Neighboring gene VPS9 domain containing 1 Neighboring gene zinc finger protein (C2H2 type) 276 Neighboring gene FA complementation group A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human CDK10 gene isoforms. Sergère JC, et al. Biochem Biophys Res Commun, 2000 Sep 16. PMID 11006117
    2. STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis. Guen VJ, et al. Cell Cycle, 2016. PMID 27104747, Free PMC Article
    3. CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. Guen VJ, et al. Proc Natl Acad Sci U S A, 2013 Nov 26. PMID 24218572, Free PMC Article
    4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112847

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cyclin-dependent protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-threonine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell cycle G2/M phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase 10
    Names
    cell division protein kinase 10
    cyclin-dependent kinase (CDC2-like) 10
    NP_001020893.2
    NP_001103406.1
    NP_001103407.1
    XP_038953809.1
    XP_038953810.1
    XP_038953811.1
    XP_038953813.1
    XP_038953814.1
    XP_063134227.1
    XP_063134228.1
    XP_063134229.1
    XP_063134230.1
    XP_063134231.1
    XP_063134232.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025722.2 → NP_001020893.2  cyclin-dependent kinase 10 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This minor variant (3) contains an alternate 5' end exon compared to transcript variant 1, and encodes a longer isoform (3) with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AI071224, BC098804
      UniProtKB/Swiss-Prot
      Q4KM47
      UniProtKB/TrEMBL
      F1LSV8
      Related
      ENSRNOP00000059465.1, ENSRNOT00000066552.5
      Conserved Domains (1) summary
      cd07845
      Location:41 → 349
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10

    2. NM_001109936.1 → NP_001103406.1  cyclin-dependent kinase 10 isoform 1

      See identical proteins and their annotated locations for NP_001103406.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the most predominant transcript and encodes isoform 1.
      Source sequence(s)
      AI071224, BC098804, DN935585, DY320517
      UniProtKB/TrEMBL
      A6IZW7, A6IZW8, G3V814
      Conserved Domains (1) summary
      cd07845
      Location:31 → 339
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10

    3. NM_001109937.1 → NP_001103407.1  cyclin-dependent kinase 10 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses a different donor splice site at the first exon compared to transcript variant 1, resulting in translation initiation from an in-frame, downstream AUG, and a shorter isoform (2) compared to isoform 1.
      Source sequence(s)
      AI071224, BC098804, DN932869
      UniProtKB/Swiss-Prot
      Q4KM47
      Conserved Domains (1) summary
      cd07845
      Location:1 → 268
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      68168040..68184923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278161.1 → XP_063134231.1  cyclin-dependent kinase 10 isoform X7

    2. XM_063278158.1 → XP_063134228.1  cyclin-dependent kinase 10 isoform X5

      UniProtKB/Swiss-Prot
      Q4KM47

    3. XM_063278160.1 → XP_063134230.1  cyclin-dependent kinase 10 isoform X6

      UniProtKB/Swiss-Prot
      Q4KM47

    4. XM_039097882.2 → XP_038953810.1  cyclin-dependent kinase 10 isoform X2

      UniProtKB/TrEMBL
      A6IZW7
      Related
      ENSRNOP00000021607.5, ENSRNOT00000021607.10
      Conserved Domains (1) summary
      cd07845
      Location:31 → 374
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10

    5. XM_039097885.2 → XP_038953813.1  cyclin-dependent kinase 10 isoform X5

      UniProtKB/Swiss-Prot
      Q4KM47
      Conserved Domains (1) summary
      cd07845
      Location:1 → 303
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10

    6. XM_039097881.2 → XP_038953809.1  cyclin-dependent kinase 10 isoform X1

      UniProtKB/Swiss-Prot
      Q4KM47
      Conserved Domains (1) summary
      cd07845
      Location:41 → 384
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10

    7. XM_063278159.1 → XP_063134229.1  cyclin-dependent kinase 10 isoform X5

      UniProtKB/Swiss-Prot
      Q4KM47

    8. XM_039097883.2 → XP_038953811.1  cyclin-dependent kinase 10 isoform X3

      UniProtKB/Swiss-Prot
      Q4KM47
      Conserved Domains (1) summary
      cd07845
      Location:41 → 373
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10

    9. XM_063278157.1 → XP_063134227.1  cyclin-dependent kinase 10 isoform X4

      UniProtKB/Swiss-Prot
      Q4KM47

    10. XM_039097886.2 → XP_038953814.1  cyclin-dependent kinase 10 isoform X5

      UniProtKB/Swiss-Prot
      Q4KM47
      Conserved Domains (1) summary
      cd07845
      Location:1 → 303
      STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10

    11. XM_063278162.1 → XP_063134232.1  cyclin-dependent kinase 10 isoform X8

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KM47.1 GenPept UniProtKB/Swiss-Prot:Q4KM47

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