Serpinb1a serpin family B member 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Serpinb1aprovided by RGD
Official Full Name: serpin family B member 1Aprovided by RGD
Primary source: RGD:1306203
See related: EnsemblRapid:ENSRNOG00000016581 AllianceGenome:RGD:1306203
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Serpinb1
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including negative regulation of cell migration; negative regulation of macromolecule metabolic process; and type B pancreatic cell proliferation. Predicted to act upstream of or within regulation of protein catabolic process. Predicted to be located in cytoplasmic ribonucleoprotein granule and extracellular region. Predicted to be active in extracellular space. Orthologous to human SERPINB1 (serpin family B member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 309.7), Spleen (RPKM 239.8) and 9 other tissues See more
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Genomic context

Location:: 17p12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (31799446..31807853)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (31590695..31599102)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (32903089..32911498)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SERPINB1 overexpression protects myocardial damage induced by acute myocardial infarction through AMPK/mTOR pathway.
Title: SERPINB1 overexpression protects myocardial damage induced by acute myocardial infarction through AMPK/mTOR pathway.
Serpinb1a induction mediates and promotes cell survival in PC12 cells.
Title: Induction of serpinb1a by PACAP or NGF is required for PC12 cells survival after serum withdrawal.
Metrnl, Dclk1 and Serpinb1a have been identified as genes that are induced during the latent process (LP) for cell differentiation with distinct temporal expression profiles and are required for subsequent neurite extension.
Title: Latent process genes for cell differentiation are common decoders of neurite extension length.

Submit: New GeneRIF Correction

General gene information

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Markers

RH132528 (e-PCR)
- UniSTS:215811

BE100150 (e-PCR)
- UniSTS:249779

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in regulation of innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytolytic granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: leukocyte elastase inhibitor A

Names: serine (or cysteine) proteinase inhibitor, clade B, member 1a; serine protease inhibitor EIA; serpin B1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031642.1 → NP_001026812.1 leukocyte elastase inhibitor A

See identical proteins and their annotated locations for NP_001026812.1

Status: PROVISIONAL

Source sequence(s)

BC098686

UniProtKB/Swiss-Prot

Q4G075

Related

ENSRNOP00000056600.2, ENSRNOT00000059854.5

Conserved Domains (1) summary

cl00137
Location:4 → 379

SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...