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    Mettl14 methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295428, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mettl14provided by RGD
    Official Full Name
    methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunitprovided by RGD
    Primary source
    RGD:1304822
    See related
    EnsemblRapid:ENSRNOG00000015250 AllianceGenome:RGD:1304822
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304822
    Summary
    Predicted to enable mRNA binding activity and mRNA m(6)A methyltransferase activity. Involved in response to nutrient levels. Predicted to be located in nucleoplasm. Predicted to be part of RNA N6-methyladenosine methyltransferase complex. Predicted to be active in nucleus. Biomarker of traumatic brain injury. Orthologous to human METTL14 (methyltransferase 14, N6-adenosine-methyltransferase non-catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 95.7), Kidney (RPKM 87.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mettl14 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (214215165..214231412, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (211530598..211546845, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (227566811..227583047, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene synaptopodin 2 Neighboring gene uncharacterized LOC134485960 Neighboring gene SEC24 homolog D, COPII coat complex component Neighboring gene RNA, U6atac small nuclear Neighboring gene elongin B, pseduogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. METTL14 regulates microglia/macrophage polarization and NLRP3 inflammasome activation after ischemic stroke by the KAT3B-STING axis. Li Y, et al. Neurobiol Dis, 2023 Sep. PMID 37541353
    2. METTL14 promotes fibroblast-like synoviocytes activation via the LASP1/SRC/AKT axis in rheumatoid arthritis. Li X, et al. Am J Physiol Cell Physiol, 2023 May 1. PMID 36878846
    3. Upregulation of UBR1 m6A Methylation by METTL14 Inhibits Autophagy in Spinal Cord Injury. Wang C, et al. eNeuro, 2023 Jun. PMID 37094938, Free PMC Article
    4. METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA. Meng L, et al. Cell Death Dis, 2022 Jan 10. PMID 35013106, Free PMC Article
    5. [Osteogenic Capacity and Mettl14 and Notch1 Expression of Adipose-Derived Stem Cells from Osteoporotic Rats]. Feng MG, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2021 May. PMID 34018360, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METTL14 promotes chondrocyte ferroptosis in osteoarthritis via m6A modification of GPX4.
      Title: METTL14 promotes chondrocyte ferroptosis in osteoarthritis via m6A modification of GPX4.
    2. METTL14 regulates microglia/macrophage polarization and NLRP3 inflammasome activation after ischemic stroke by the KAT3B-STING axis.
      Title: METTL14 regulates microglia/macrophage polarization and NLRP3 inflammasome activation after ischemic stroke by the KAT3B-STING axis.
    3. Upregulation of UBR1 m6A Methylation by METTL14 Inhibits Autophagy in Spinal Cord Injury.
      Title: Upregulation of UBR1 m6A Methylation by METTL14 Inhibits Autophagy in Spinal Cord Injury.
    4. METTL14 promotes fibroblast-like synoviocytes activation via the LASP1/SRC/AKT axis in rheumatoid arthritis.
      Title: METTL14 promotes fibroblast-like synoviocytes activation via the LASP1/SRC/AKT axis in rheumatoid arthritis.
    5. METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA.
      Title: METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA.
    6. [Osteogenic Capacity and Mettl14 and Notch1 Expression of Adipose-Derived Stem Cells from Osteoporotic Rats].
      Title: [Osteogenic Capacity and Mettl14 and Notch1 Expression of Adipose-Derived Stem Cells from Osteoporotic Rats].
    7. N6-methyladenosine methyltransferase plays a role in hypoxic preconditioning partially through the interaction with lncRNA H19.
      Title: N6-methyladenosine methyltransferase plays a role in hypoxic preconditioning partially through the interaction with lncRNA H19.
    8. our results demonstrated the functional importance of METTL14-dependent vascular m6A methylome in vascular functions during calcification and provided a novel mechanistic insight to the therapeutic mechanisms of METTL14
      Title: METTL14-dependent m6A regulates vascular calcification induced by indoxyl sulfate.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables S-adenosyl-L-methionine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables mRNA m(6)A methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA m(6)A methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in forebrain radial glial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in gliogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of negative regulation of hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA N6-methyladenosine methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N6-adenosine-methyltransferase non-catalytic subunit
    Names
    N6-adenosine-methyltransferase subunit METTL14
    methyltransferase 14, N6-adenosine-methyltransferase subunit
    methyltransferase like 14
    methyltransferase-like protein 14
    NP_001386178.1
    XP_038958022.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399249.1 → NP_001386178.1  N6-adenosine-methyltransferase non-catalytic subunit

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6HVI9, A6HVJ1, B2RYI4, D4A701, F7F7M4
      Related
      ENSRNOP00000020574.5, ENSRNOT00000020574.9
      Conserved Domains (1) summary
      pfam05063
      Location:186 → 363
      MT-A70

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      214215165..214231412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102094.2 → XP_038958022.1  N6-adenosine-methyltransferase non-catalytic subunit isoform X1

      Conserved Domains (1) summary
      pfam05063
      Location:19 → 196
      MT-A70

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106470.1: Suppressed sequence

      Description
      NM_001106470.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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