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    Nceh1 neutral cholesterol ester hydrolase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294930, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nceh1provided by RGD
    Official Full Name
    neutral cholesterol ester hydrolase 1provided by RGD
    Primary source
    RGD:1311104
    See related
    EnsemblRapid:ENSRNOG00000013313 AllianceGenome:RGD:1311104
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Aadacl1; RGD1311104
    Summary
    Predicted to enable phosphate ion binding activity and serine hydrolase activity. Predicted to be involved in ether lipid metabolic process. Predicted to act upstream of or within protein dephosphorylation and xenobiotic metabolic process. Predicted to be located in membrane. Orthologous to human NCEH1 (neutral cholesterol ester hydrolase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 281.1), Heart (RPKM 254.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nceh1 in Genome Data Viewer
    Location:
    2q24
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (112003677..112064274)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (110074985..110135592)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (112868834..112932622)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555118 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene epithelial cell transforming 2 Neighboring gene uncharacterized LOC134485890 Neighboring gene mitochondrial ribosomal protein L54, pseudogene 1 Neighboring gene uncharacterized LOC120100787

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A brain detoxifying enzyme for organophosphorus nerve poisons. Nomura DK, et al. Proc Natl Acad Sci U S A, 2005 Apr 26. PMID 15840715, Free PMC Article
    2. TGF-β/Smad2/3 signaling directly regulates several miRNAs in mouse ES cells and early embryos. Redshaw N, et al. PLoS One, 2013. PMID 23390484, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acetylalkylglycerol acetylhydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphate ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ether lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ether lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neutral cholesterol ester hydrolase 1
    Names
    2-acetyl MAGE hydrolase
    NCEH
    acetylalkylglycerol acetylhydrolase
    arylacetamide deacetylase-like 1
    NP_001120996.1
    XP_038957906.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127524.2 → NP_001120996.1  neutral cholesterol ester hydrolase 1

      See identical proteins and their annotated locations for NP_001120996.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166533
      UniProtKB/Swiss-Prot
      B2GV54
      UniProtKB/TrEMBL
      A0A8I6AE54
      Related
      ENSRNOP00000017805.5, ENSRNOT00000017805.9
      Conserved Domains (2) summary
      COG0657
      Location:70 → 385
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam07859
      Location:109 → 382
      Abhydrolase_3; alpha/beta hydrolase fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      112003677..112064274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101978.2 → XP_038957906.1  neutral cholesterol ester hydrolase 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2GV54.1 GenPept UniProtKB/Swiss-Prot:B2GV54

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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