Mcm2 minichromosome maintenance complex component 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mcm2provided by RGD
Official Full Name: minichromosome maintenance complex component 2provided by RGD
Primary source: RGD:1305577
See related: EnsemblRapid:ENSRNOG00000016316 AllianceGenome:RGD:1305577
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA binding activity; enzyme binding activity; and histone binding activity. Predicted to contribute to 3'-5' DNA helicase activity and single-stranded DNA helicase activity. Predicted to be involved in DNA metabolic process; apoptotic process; and cochlea development. Predicted to act upstream of or within cellular response to interleukin-4 and nucleosome assembly. Predicted to be located in chromatin; cytoplasm; and nucleoplasm. Predicted to be part of CMG complex; MCM complex; and nuclear origin of replication recognition complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease and autosomal dominant nonsyndromic deafness 70. Orthologous to human MCM2 (minichromosome maintenance complex component 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 288.6), Spleen (RPKM 187.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (122903679..122918205, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (121346434..121360962, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (120825699..120840221, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mcm2 (e-PCR), detects polymorphism
- UniSTS:547455

RH142663 (e-PCR)
- UniSTS:231910

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to 3'-5' DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H2AZ histone chaperone activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent H3-H4 histone complex chaperone activity	IEA Inferred from Electronic Annotation more info
enables DNA clamp loader activity	IEA Inferred from Electronic Annotation more info
enables DNA replication origin binding	ISO Inferred from Sequence Orthology more info
enables chromatin extrusion motor activity	IEA Inferred from Electronic Annotation more info
enables cohesin loader activity	IEA Inferred from Electronic Annotation more info
enables double-stranded DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables forked DNA-dependent helicase activity	IEA Inferred from Electronic Annotation more info
enables four-way junction helicase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables single-stranded 3'-5' DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to single-stranded DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA replication initiation	ISO Inferred from Sequence Orthology more info
involved_in DNA unwinding involved in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA unwinding involved in DNA replication	ISO Inferred from Sequence Orthology more info
involved_in DNA unwinding involved in DNA replication	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to interleukin-4	ISO Inferred from Sequence Orthology more info
involved_in chromatin looping	IEA Inferred from Electronic Annotation more info
involved_in cochlea development	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via break-induced replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic DNA replication initiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nucleosome assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CMG complex	ISO Inferred from Sequence Orthology more info
part_of MCM complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MCM complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of nuclear origin of replication recognition complex	ISO Inferred from Sequence Orthology more info
NOT located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA replication licensing factor MCM2

Names: minichromosome maintenance deficient 2 mitotin

NP_001101343.2

EC 3.6.4.12

XP_006236925.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107873.2 → NP_001101343.2 DNA replication licensing factor MCM2

See identical proteins and their annotated locations for NP_001101343.2

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

D3ZP96

Related

ENSRNOP00000022231.5, ENSRNOT00000022231.8

Conserved Domains (4) summary

smart00350
Location:292 → 804

MCM; minichromosome maintenance proteins

pfam12619
Location:73 → 183

MCM2_N; Mini-chromosome maintenance protein 2

pfam14551
Location:199 → 311

MCM_N; MCM N-terminal domain

cl21455
Location:486 → 633

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

122903679..122918205 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236863.3 → XP_006236925.1 DNA replication licensing factor MCM2 isoform X1

See identical proteins and their annotated locations for XP_006236925.1

UniProtKB/TrEMBL

D3ZP96

Conserved Domains (4) summary

smart00350
Location:292 → 804

MCM; minichromosome maintenance proteins

pfam12619
Location:73 → 183

MCM2_N; Mini-chromosome maintenance protein 2

pfam14551
Location:199 → 311

MCM_N; MCM N-terminal domain

cl21455
Location:486 → 633

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases