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    Slc7a6 solute carrier family 7 member 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307811, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc7a6provided by RGD
    Official Full Name
    solute carrier family 7 member 6provided by RGD
    Primary source
    RGD:1309193
    See related
    EnsemblRapid:ENSRNOG00000019943 AllianceGenome:RGD:1309193
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Y+LAT2; y+LAT-2
    Summary
    Predicted to enable L-lysine:L-arginine antiporter activity and arginine binding activity. Involved in L-arginine transmembrane transport and nitric oxide biosynthetic process. Predicted to be located in plasma membrane. Orthologous to human SLC7A6 (solute carrier family 7 member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 121.3), Thymus (RPKM 98.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc7a6 in Genome Data Viewer
    Location:
    19q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50982459..51010140)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (34073472..34100268)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (38152225..38179149)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T-cells 3 Neighboring gene epithelial splicing regulatory protein 2 Neighboring gene phospholipase A2, group XV Neighboring gene solute carrier family 7, member 6 opposite strand Neighboring gene protein arginine methyltransferase 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Upregulation of the heteromeric y⁺LAT2 transporter contributes to ammonia-induced increase of arginine uptake in rat cerebral cortical astrocytes. Zielińska M, et al. Neurochem Int, 2012 Sep. PMID 22401943
    2. Induction of inducible nitric oxide synthase expression in ammonia-exposed cultured astrocytes is coupled to increased arginine transport by upregulated y(+)LAT2 transporter. Zielińska M, et al. J Neurochem, 2015 Dec. PMID 26448619
    3. Ornithine transport via cationic amino acid transporter-1 is involved in ornithine cytotoxicity in retinal pigment epithelial cells. Kaneko S, et al. Invest Ophthalmol Vis Sci, 2007 Jan. PMID 17197568
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-arginine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-lysine:L-arginine antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-lysine:L-arginine antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-lysine:L-arginine antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables arginine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables arginine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables basic amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-arginine transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in L-arginine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-leucine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-leucine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-lysine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycine betaine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycine betaine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutral amino acid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nitric oxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ornithine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ornithine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Y+L amino acid transporter 2
    Names
    solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
    solute carrier family 7 (cationic amino acid transporter, y+ system), member 6
    y(+)L-type amino acid transporter 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107424.1 → NP_001100894.1  Y+L amino acid transporter 2

      See identical proteins and their annotated locations for NP_001100894.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/Swiss-Prot
      D3ZMM8
      Related
      ENSRNOP00000027117.3, ENSRNOT00000027117.6
      Conserved Domains (1) summary
      TIGR00911
      Location:17 → 501
      2A0308; L-type amino acid transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      50982459..51010140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772500.4 → XP_008770722.1  Y+L amino acid transporter 2 isoform X3

      See identical proteins and their annotated locations for XP_008770722.1

      UniProtKB/Swiss-Prot
      D3ZMM8
      Conserved Domains (1) summary
      TIGR00911
      Location:17 → 501
      2A0308; L-type amino acid transporter

    2. XM_008772501.4 → XP_008770723.1  Y+L amino acid transporter 2 isoform X3

      See identical proteins and their annotated locations for XP_008770723.1

      UniProtKB/Swiss-Prot
      D3ZMM8
      Conserved Domains (1) summary
      TIGR00911
      Location:17 → 501
      2A0308; L-type amino acid transporter

    3. XM_039097744.2 → XP_038953672.1  Y+L amino acid transporter 2 isoform X3

      UniProtKB/Swiss-Prot
      D3ZMM8
      Conserved Domains (1) summary
      TIGR00911
      Location:17 → 501
      2A0308; L-type amino acid transporter

    4. XM_039097745.2 → XP_038953673.1  Y+L amino acid transporter 2 isoform X4

      Conserved Domains (1) summary
      TIGR00911
      Location:128 → 453
      2A0308; L-type amino acid transporter

    5. XM_039097743.2 → XP_038953671.1  Y+L amino acid transporter 2 isoform X2

      Conserved Domains (1) summary
      TIGR00911
      Location:127 → 511
      2A0308; L-type amino acid transporter

    6. XM_008772502.3 → XP_008770724.1  Y+L amino acid transporter 2 isoform X3

      See identical proteins and their annotated locations for XP_008770724.1

      UniProtKB/Swiss-Prot
      D3ZMM8
      Conserved Domains (1) summary
      TIGR00911
      Location:17 → 501
      2A0308; L-type amino acid transporter

    7. XM_063278036.1 → XP_063134106.1  Y+L amino acid transporter 2 isoform X6

    8. XM_063278038.1 → XP_063134108.1  Y+L amino acid transporter 2 isoform X6

    9. XM_063278037.1 → XP_063134107.1  Y+L amino acid transporter 2 isoform X6

    10. XM_006255500.5 → XP_006255562.1  Y+L amino acid transporter 2 isoform X3

      See identical proteins and their annotated locations for XP_006255562.1

      UniProtKB/Swiss-Prot
      D3ZMM8
      Conserved Domains (1) summary
      TIGR00911
      Location:17 → 501
      2A0308; L-type amino acid transporter

    11. XM_006255498.5 → XP_006255560.1  Y+L amino acid transporter 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZKR1
      Related
      ENSRNOP00000078355.1, ENSRNOT00000094705.2
      Conserved Domains (1) summary
      TIGR00911
      Location:30 → 514
      2A0308; L-type amino acid transporter

    12. XM_039097746.2 → XP_038953674.2  Y+L amino acid transporter 2 isoform X5

    13. XM_063278041.1 → XP_063134111.1  Y+L amino acid transporter 2 isoform X8

    14. XM_063278040.1 → XP_063134110.1  Y+L amino acid transporter 2 isoform X8

    15. XM_063278039.1 → XP_063134109.1  Y+L amino acid transporter 2 isoform X7

    RNA

    1. XR_010060001.1 RNA Sequence

    2. XR_010059998.1 RNA Sequence

    3. XR_010059999.1 RNA Sequence

    4. XR_597221.4 RNA Sequence

    5. XR_010060002.1 RNA Sequence

    6. XR_010060000.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZMM8.1 GenPept UniProtKB/Swiss-Prot:D3ZMM8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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