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    Pex5l peroxisomal biogenesis factor 5-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286937, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pex5lprovided by RGD
    Official Full Name
    peroxisomal biogenesis factor 5-likeprovided by RGD
    Primary source
    RGD:708407
    See related
    EnsemblRapid:ENSRNOG00000011211 AllianceGenome:RGD:708407
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pex2; TRIP8b; Trjip8b
    Summary
    Enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity and small GTPase binding activity. Involved in positive regulation of corticotropin secretion; regulated exocytosis; and regulation of cAMP-mediated signaling. Located in cell tip and perinuclear region of cytoplasm. Part of intracellular cyclic nucleotide activated cation channel complex. Orthologous to human PEX5L (peroxisomal biogenesis factor 5 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 374.3) and Testes (RPKM 120.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pex5l in Genome Data Viewer
    Location:
    2q24
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (117623199..117836772, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (115694868..115908365, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (119330330..119405809, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA70 Neighboring gene ubiquitin specific peptidase 13 Neighboring gene uncharacterized LOC134485614 Neighboring gene uncharacterized LOC134485613 Neighboring gene uncharacterized LOC120100799 Neighboring gene small nucleolar RNA SNORA48

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Association of adaptor protein TRIP8b with clathrin. Popova NV, et al. J Neurochem, 2011 Sep. PMID 21749376, Free PMC Article
    2. Analysis of proteins interacting with TRIP8b adapter. Popova NV, et al. Biochemistry (Mosc), 2008 Jun. PMID 18620529
    3. Phosphorylation of the HCN channel auxiliary subunit TRIP8b is altered in an animal model of temporal lobe epilepsy and modulates channel function. Foote KM, et al. J Biol Chem, 2019 Oct 25. PMID 31492750, Free PMC Article
    4. Corticospinal-specific HCN expression in mouse motor cortex: I(h)-dependent synaptic integration as a candidate microcircuit mechanism involved in motor control. Sheets PL, et al. J Neurophysiol, 2011 Nov. PMID 21795621, Free PMC Article
    5. Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation. Zolles G, et al. Neuron, 2009 Jun 25. PMID 19555650

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. loss of TRIP8b phosphorylation may affect HCN channel properties during epileptogenesis.
      Title: Phosphorylation of the HCN channel auxiliary subunit TRIP8b is altered in an animal model of temporal lobe epilepsy and modulates channel function.
    2. Nedd4-2 plays an important role in the regulation of HCN1 trafficking and may compete with TRIP8b(1a-4) in this process
      Title: Nedd4-2 regulates surface expression and may affect N-glycosylation of hyperpolarization-activated cyclic nucleotide-gated (HCN)-1 channels.
    3. TRIP8b isoforms are important regulators of HCN1 trafficking in entorhinal neurons.
      Title: Regulation of axonal HCN1 trafficking in perforant path involves expression of specific TRIP8b isoforms.
    4. Hyperpolarization current expression was high in corticospinal neurons and low in corticostriatal and corticocortical neurons, a pattern mirrored by mRNA levels for HCN1 and Trip8b subunits.
      Title: Corticospinal-specific HCN expression in mouse motor cortex: I(h)-dependent synaptic integration as a candidate microcircuit mechanism involved in motor control.
    5. Our data suggest complex regulatory functions of TRIP8b in neuronal endocytosis through independent interaction with membrane proteins and components of the clathrin coat
      Title: Association of adaptor protein TRIP8b with clathrin.
    6. increasing cAMP levels in cells antagonized the up-regulation of HCN1 channels mediated by a TRIP8b construct binding the CNBD exclusively.
      Title: Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites.
    7. although TRIP8b exists in multiple splice isoforms, our data suggest that the predominant role of this protein in brain is to promote h channel surface expression and enhance its current
      Title: Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function.
    8. A role of TRIP8b in receptor-mediated endocytosis.
      Title: Analysis of proteins interacting with TRIP8b adapter.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peroxisome matrix targeting signal-1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peroxisome matrix targeting signal-1 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peroxisome targeting sequence binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peroxisome targeting sequence binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within maintenance of protein location ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of corticotropin secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix, docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulated exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of intracellular cyclic nucleotide activated cation channel complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    PEX5-related protein
    Names
    PEX5-like protein
    TPR-containing Rab8b-interacting protein
    peroxin 2
    peroxin-5-related protein
    pex5Rp
    tetratricopeptide repeat-containing Rab8b-interacting protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393823.2 → NP_001380752.1  PEX5-related protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q925N3
      UniProtKB/TrEMBL
      A0A8I6AHG5
      Conserved Domains (2) summary
      TIGR02917
      Location:353 → 583
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:496 → 524
      TPR; TPR repeat [structural motif]

    2. NM_001393824.2 → NP_001380753.1  PEX5-related protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q925N3
      Conserved Domains (2) summary
      TIGR02917
      Location:296 → 526
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:439 → 467
      TPR; TPR repeat [structural motif]

    3. NM_001393825.2 → NP_001380754.1  PEX5-related protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q925N3
      UniProtKB/TrEMBL
      A0A8I6AGZ2, A6IHR5
      Conserved Domains (2) summary
      TIGR02917
      Location:272 → 502
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:415 → 443
      TPR; TPR repeat [structural motif]

    4. NM_001393826.2 → NP_001380755.1  PEX5-related protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q925N3
      Related
      ENSRNOP00000082985.2, ENSRNOT00000097356.2
      Conserved Domains (2) summary
      TIGR02917
      Location:331 → 561
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:474 → 502
      TPR; TPR repeat [structural motif]

    5. NM_001393827.2 → NP_001380756.1  PEX5-related protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q925N3
      UniProtKB/TrEMBL
      A0A8I6G884
      Conserved Domains (2) summary
      TIGR02917
      Location:355 → 585
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:498 → 526
      TPR; TPR repeat [structural motif]

    6. NM_001393828.2 → NP_001380757.1  PEX5-related protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q925N3
      Conserved Domains (2) summary
      TIGR02917
      Location:330 → 560
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:473 → 501
      TPR; TPR repeat [structural motif]

    7. NM_001393829.2 → NP_001380758.1  PEX5-related protein isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q925N3
      UniProtKB/TrEMBL
      A0A8I6A617, A6IHR7
      Related
      ENSRNOP00000095922.2, ENSRNOT00000098944.2
      Conserved Domains (2) summary
      TIGR02917
      Location:320 → 550
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:463 → 491
      TPR; TPR repeat [structural motif]

    8. NM_001393830.2 → NP_001380759.1  PEX5-related protein isoform 9

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q925N3
      Conserved Domains (2) summary
      TIGR02917
      Location:295 → 525
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:438 → 466
      TPR; TPR repeat [structural motif]

    9. NM_001393831.2 → NP_001380760.1  PEX5-related protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q925N3
      UniProtKB/TrEMBL
      A0A8I6G884
      Conserved Domains (2) summary
      TIGR02917
      Location:355 → 585
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:498 → 526
      TPR; TPR repeat [structural motif]

    10. NM_173152.4 → NP_775175.2  PEX5-related protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q925N3
      UniProtKB/TrEMBL
      A0A8I6AHT0, A6IHR6
      Related
      ENSRNOP00000111871.1, ENSRNOT00000147186.1
      Conserved Domains (2) summary
      TIGR02917
      Location:307 → 537
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:450 → 478
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      117623199..117836772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281429.1 → XP_063137499.1  PEX5-related protein isoform X18

      UniProtKB/Swiss-Prot
      Q925N3
      Related
      ENSRNOP00000102744.1, ENSRNOT00000129287.1

    2. XM_063281424.1 → XP_063137494.1  PEX5-related protein isoform X14

      UniProtKB/Swiss-Prot
      Q925N3
      Related
      ENSRNOP00000107978.1, ENSRNOT00000170544.1

    3. XM_063281421.1 → XP_063137491.1  PEX5-related protein isoform X11

      UniProtKB/Swiss-Prot
      Q925N3
      UniProtKB/TrEMBL
      A0A8I6B1I9
      Related
      ENSRNOP00000100252.1, ENSRNOT00000141428.1

    4. XM_063281420.1 → XP_063137490.1  PEX5-related protein isoform X10

      UniProtKB/Swiss-Prot
      Q925N3

    5. XM_063281426.1 → XP_063137496.1  PEX5-related protein isoform X15

      UniProtKB/Swiss-Prot
      Q925N3

    6. XM_063281417.1 → XP_063137487.1  PEX5-related protein isoform X8

      UniProtKB/Swiss-Prot
      Q925N3

    7. XM_063281415.1 → XP_063137485.1  PEX5-related protein isoform X6

      UniProtKB/Swiss-Prot
      Q925N3

    8. XM_063281432.1 → XP_063137502.1  PEX5-related protein isoform X19

    9. XM_063281428.1 → XP_063137498.1  PEX5-related protein isoform X17

      UniProtKB/Swiss-Prot
      Q925N3

    10. XM_063281427.1 → XP_063137497.1  PEX5-related protein isoform X16

      UniProtKB/Swiss-Prot
      Q925N3
      UniProtKB/TrEMBL
      A0A8I6AMT2

    11. XM_063281418.1 → XP_063137488.1  PEX5-related protein isoform X9

      UniProtKB/Swiss-Prot
      Q925N3

    12. XM_063281416.1 → XP_063137486.1  PEX5-related protein isoform X7

      UniProtKB/Swiss-Prot
      Q925N3

    13. XM_063281419.1 → XP_063137489.1  PEX5-related protein isoform X5

      UniProtKB/Swiss-Prot
      Q925N3
      UniProtKB/TrEMBL
      A0A8I6G884
      Related
      ENSRNOP00000086465.2, ENSRNOT00000107964.2

    14. XM_063281423.1 → XP_063137493.1  PEX5-related protein isoform X13

      UniProtKB/Swiss-Prot
      Q925N3
      UniProtKB/TrEMBL
      A0A8I6A617, A6IHR7

    15. XM_063281422.1 → XP_063137492.1  PEX5-related protein isoform X12

      UniProtKB/Swiss-Prot
      Q925N3

    16. XM_063281413.1 → XP_063137483.1  PEX5-related protein isoform X5

      UniProtKB/Swiss-Prot
      Q925N3
      UniProtKB/TrEMBL
      A0A8I6G884

    17. XM_063281412.1 → XP_063137482.1  PEX5-related protein isoform X4

      UniProtKB/Swiss-Prot
      Q925N3

    18. XM_063281410.1 → XP_063137480.1  PEX5-related protein isoform X2

      UniProtKB/Swiss-Prot
      Q925N3

    19. XM_063281409.1 → XP_063137479.1  PEX5-related protein isoform X1

      UniProtKB/Swiss-Prot
      Q925N3

    20. XM_063281411.1 → XP_063137481.1  PEX5-related protein isoform X3

      UniProtKB/Swiss-Prot
      Q925N3

    21. XM_063281430.1 → XP_063137500.1  PEX5-related protein isoform X19

    22. XM_063281431.1 → XP_063137501.1  PEX5-related protein isoform X19

    23. XM_063281434.1 → XP_063137504.1  PEX5-related protein isoform X21

    24. XM_063281435.1 → XP_063137505.1  PEX5-related protein isoform X21

    25. XM_063281433.1 → XP_063137503.1  PEX5-related protein isoform X20

    26. XM_063281436.1 → XP_063137506.1  PEX5-related protein isoform X22

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q925N3.1 GenPept UniProtKB/Swiss-Prot:Q925N3

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