Dnm3 dynamin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnm3provided by RGD
Official Full Name: dynamin 3provided by RGD
Primary source: RGD:727949
See related: EnsemblRapid:ENSRNOG00000026490 AllianceGenome:RGD:727949
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: dynamin-2
Summary: Enables G protein-coupled glutamate receptor binding activity; GTPase activity; and enzyme binding activity. A structural constituent of postsynapse. Involved in several processes, including filopodium assembly; positive regulation of synaptic vesicle recycling; and regulation of plasma membrane bounded cell projection organization. Located in several cellular components, including dendritic spine head; postsynaptic density; and synaptic cleft. Part of apical tubulobulbar complex and basal tubulobulbar complex. Is active in glutamatergic synapse and postsynaptic endocytic zone membrane. Orthologous to human DNM3 (dynamin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 130.7), Adrenal (RPKM 65.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q22

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (76892381..77371346, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (74359043..74838135, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (79906711..80379967, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DNM2 mediates HF by modulating Ca(2+)-dependent apoptotic death of cardiomyocyte.
Title: Dynamin-2 mediates heart failure by modulating Ca2+ -dependent cardiomyocyte apoptosis.
dynamin isoforms select appropriate vesicle reuse pathways associated with specific neuronal firing patterns
Title: Dynamin isoforms decode action potential firing for synaptic vesicle recycling.
These results strongly suggest that dynamin 2 is involved in actin dynamics and the formation of dynamin 2-positive ruffles during phagocytosis.
Title: Dynamin 2 is required for actin assembly in phagocytosis in Sertoli cells.
an enhanced interaction between a specific Dyn3 splice variant and cortactin modulate actin-membrane dynamics in developing neurons to regulate the morphogenesis of dendritic spines
Title: A dynamin-3 spliced variant modulates the actin/cortactin-dependent morphogenesis of dendritic spines.
Our findings are consistent with the conclusion that dynamin 3 is involved with tubulobulbar morphogenesis.
Title: The role of dynamin 3 in the testis.
identified a novel dynamin III mRNA that was up-regulated in the hypothyroid state; the 7.2 kb dynamin III transcript is brain-specific and selectively regulated by thyroid hormone status.
Title: A novel dynamin III isoform is up-regulated in the central nervous system in hypothyroidism.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D13Mit5 (e-PCR), detects polymorphism
- UniSTS:119300

AW534587 (e-PCR)
- UniSTS:246594

BQ200675 (e-PCR)
- UniSTS:260676

AA800783 (e-PCR)
- UniSTS:249961

BE116196 (e-PCR)
- UniSTS:248451

D13Mit3 (e-PCR), detects polymorphism
- UniSTS:119440

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables GTPase activity	TAS Traceable Author Statement more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables nitric-oxide synthase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of postsynapse	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
enables type 1 metabotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables type 5 metabotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in filopodium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of dendritic spine morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of filopodium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of synaptic vesicle recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynapse organization	IEA Inferred from Electronic Annotation more info
involved_in receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm ejaculation	NAS Non-traceable Author Statement more info	PubMed
involved_in synapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic vesicle budding from presynaptic endocytic zone membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
part_of apical tubulobulbar complex	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
part_of basal tubulobulbar complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine head	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic endocytic zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic endocytic zone membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic cleft	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dynamin-3

Names: T-dynamin; dynamin, testicular; testicular dynamin

NP_612547.1

EC 3.6.5.5

XP_006250203.1

EC 3.6.5.5

XP_006250204.1

EC 3.6.5.5

XP_038946240.1

EC 3.6.5.5

XP_038946241.1

EC 3.6.5.5

XP_038946244.1

EC 3.6.5.5

XP_063128083.1

EC 3.6.5.5

XP_063128084.1

EC 3.6.5.5

XP_063128085.1

EC 3.6.5.5

XP_063128086.1

EC 3.6.5.5

XP_063128087.1

EC 3.6.5.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138538.2 → NP_612547.1 dynamin-3

See identical proteins and their annotated locations for NP_612547.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q08877, Q9QXL9

UniProtKB/TrEMBL

A0A8I6A9X4

Related

ENSRNOP00000063767.1, ENSRNOT00000067653.5

Conserved Domains (6) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

COG0699
Location:79 → 744

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam04554
Location:769 → 832

Extensin_2; Extensin-like region

cd01256
Location:526 → 635

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:217 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:657 → 745

GED; Dynamin GTPase effector domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

76892381..77371346 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063272014.1 → XP_063128084.1 dynamin-3 isoform X3

UniProtKB/TrEMBL

A0A8I6A9X4

Related

ENSRNOP00000084111.2, ENSRNOT00000102382.2
XM_063272015.1 → XP_063128085.1 dynamin-3 isoform X5

UniProtKB/TrEMBL

A0A8I6A9X4

Related

ENSRNOP00000088404.1, ENSRNOT00000104847.2
XM_006250141.5 → XP_006250203.1 dynamin-3 isoform X1

UniProtKB/TrEMBL

A0A8I6A9X4

Conserved Domains (6) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

COG0699
Location:79 → 734

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

pfam04554
Location:759 → 822

Extensin_2; Extensin-like region

cd01256
Location:514 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:217 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:647 → 735

GED; Dynamin GTPase effector domain
XM_006250142.5 → XP_006250204.1 dynamin-3 isoform X4

See identical proteins and their annotated locations for XP_006250204.1

UniProtKB/TrEMBL

A0A8I6A9X4

Conserved Domains (6) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

COG0699
Location:79 → 734

CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]

cd01256
Location:514 → 625

PH_dynamin; Dynamin pleckstrin homology (PH) domain

pfam01031
Location:217 → 502

Dynamin_M; Dynamin central region

pfam02212
Location:647 → 735

GED; Dynamin GTPase effector domain

pfam10630
Location:749 → 837

DUF2476; Protein of unknown function (DUF2476)
XM_063272013.1 → XP_063128083.1 dynamin-3 isoform X2

UniProtKB/TrEMBL

A0A8I6A9X4

Related

ENSRNOP00000068044.2, ENSRNOT00000075938.3
XM_063272017.1 → XP_063128087.1 dynamin-3 isoform X7
XM_063272016.1 → XP_063128086.1 dynamin-3 isoform X6
XM_039090312.2 → XP_038946240.1 dynamin-3 isoform X8

Conserved Domains (2) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region
XM_039090313.2 → XP_038946241.1 dynamin-3 isoform X8

Conserved Domains (2) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

pfam01031
Location:216 → 502

Dynamin_M; Dynamin central region
XM_039090316.2 → XP_038946244.1 dynamin-3 isoform X9

Conserved Domains (2) summary

smart00053
Location:6 → 245

DYNc; Dynamin, GTPase

pfam01031
Location:216 → 498

Dynamin_M; Dynamin central region