Clec4f C-type lectin domain family 4, member F [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Clec4fprovided by RGD
Official Full Name: C-type lectin domain family 4, member Fprovided by RGD
Primary source: RGD:621062
See related: EnsemblRapid:ENSRNOG00000013137 AllianceGenome:RGD:621062
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kclr; Clecsf13
Summary: Predicted to enable galactose binding activity; glycolipid binding activity; and pattern recognition receptor activity. Involved in positive regulation of gene expression. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human CLEC4F (C-type lectin domain family 4 member F). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 747.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (117686686..117696407, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (116129023..116138744, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (115322300..115332021, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The receptor displays monosaccharide-binding characteristics similar to the hepatic asialoglycoprotein receptor, but with somewhat less selectivity
Title: Molecular characterization of the rat Kupffer cell glycoprotein receptor.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate binding	TAS Traceable Author Statement more info	PubMed
enables galactose binding	ISO Inferred from Sequence Orthology more info
enables glycolipid binding	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within NK T cell activation	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	HMP more info	PubMed

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-type lectin domain family 4 member F

Names: C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 13; C-type lectin 13; C-type lectin superfamily member 13; Kupffer cell receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053753.1 → NP_446205.1 C-type lectin domain family 4 member F

See identical proteins and their annotated locations for NP_446205.1

Status: PROVISIONAL

Source sequence(s)

M55532

UniProtKB/Swiss-Prot

P10716, Q4KMB0

UniProtKB/TrEMBL

A6IAN7

Related

ENSRNOP00000017643.2, ENSRNOT00000017643.6

Conserved Domains (2) summary

cd03590
Location:414 → 538

CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

TIGR02168
Location:100 → 390

SMC_prok_B; chromosome segregation protein SMC, common bacterial type