S100a7a S100 calcium binding protein A7A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: S100a7aprovided by RGD
Official Full Name: S100 calcium binding protein A7Aprovided by RGD
Primary source: RGD:1593779
See related: EnsemblRapid:ENSRNOG00000082037 AllianceGenome:RGD:1593779
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: S100a15
Summary: Predicted to enable several functions, including calcium-dependent protein binding activity; chemoattractant activity; and identical protein binding activity. Predicted to be involved in positive chemotaxis. Predicted to act upstream of or within inflammatory response. Predicted to be located in cytosol. Predicted to be active in cytoplasm and extracellular space. Orthologous to human S100A7A (S100 calcium binding protein A7A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 1.4) and Muscle (RPKM 0.4) See more
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Genomic context

Location:: 2q34

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (178448983..178453424)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (176151405..176155846)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (190058093..190063132)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

d2rat110 (e-PCR)
- UniSTS:121617

RH128552 (e-PCR)
- UniSTS:211860

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables chemoattractant activity	IBA Inferred from Biological aspect of Ancestor more info
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in endothelial cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive chemotaxis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein S100-A15A

Names: S100 calcium binding protein A15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109471.1 → NP_001102941.1 protein S100-A15A

See identical proteins and their annotated locations for NP_001102941.1

Status: PROVISIONAL

Source sequence(s)

CH473976

UniProtKB/TrEMBL

A6J6Q2, D3ZDM0

Related

ENSRNOP00000112077.1, ENSRNOT00000158012.1

Conserved Domains (1) summary

cd00213
Location:4 → 93

S-100; S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 proteins are ...