Hes5 hes family bHLH transcription factor 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hes5provided by RGD
Official Full Name: hes family bHLH transcription factor 5provided by RGD
Primary source: RGD:621340
See related: EnsemblRapid:ENSRNOG00000013850 AllianceGenome:RGD:621340
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables chromatin binding activity and double-stranded DNA binding activity. Involved in several processes, including generation of neurons; negative regulation of cell differentiation; and neuronal stem cell population maintenance. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Biomarker of diabetes mellitus. Orthologous to human HES5 (hes family bHLH transcription factor 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 61.0), Brain (RPKM 55.3) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (170804511..170807988)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (165522138..165523684)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (172364421..172365188)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Monocrotaline-induced pulmonary hypertension rats had high expressions of the Notch3-HES5 signal pathway in the pulmonary arterioles.
Title: Exploration of the Notch3-HES5 signal pathway in monocrotaline-induced pulmonary hypertension using rat model.
Folic acid stimulated the expression of Notch1, Hes1, and Hes5 proteins, and this effect increased with folic acid dose in the rat middle cerebral artery occlusion model of stroke.
Title: Folic acid enhances Notch signaling, hippocampal neurogenesis, and cognitive function in a rat model of cerebral ischemia.
Hes5 was not expressed on postnatal days 0 - 5 in rat greater epithelial ridge cells.
Title: [Expression of three kinds of transcription factors in greater epithelial ridge cells of rat cochlear].
The levels of Hes5 mRNA decreased on days 1 and 3 after the start of reperfusion and the decreased levels of the mRNA returned to the basal level by 5 days after ischemia.
Title: Changes in the expression of Hes5 and Mash1 mRNA in the adult rat dentate gyrus after transient forebrain ischemia.
Hes5 does not promote astrocyte differentiation
Title: Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:484887 (e-PCR)
- UniSTS:484887

UniSTS:259615 (e-PCR)
- UniSTS:259615

Hes5 (e-PCR), detects polymorphism
- UniSTS:259615

UniSTS:265716 (e-PCR)
- UniSTS:265716

Hes5 (e-PCR), detects polymorphism
- UniSTS:265716

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in S-shaped body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in astrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in brain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in camera-type eye development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cartilage development	ISO Inferred from Sequence Orthology more info
involved_in cartilage development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell maturation	ISO Inferred from Sequence Orthology more info
involved_in cell maturation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within central nervous system myelination	ISO Inferred from Sequence Orthology more info
involved_in central nervous system myelination	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
NOT involved_in chondrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in comma-shaped body morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of epithelial cell polarity	ISO Inferred from Sequence Orthology more info
involved_in forebrain radial glial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glial cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in glial cell fate commitment	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of inner ear auditory receptor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
involved_in metanephric nephron tubule morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of astrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of forebrain neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of inner ear auditory receptor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inner ear receptor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of oligodendrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of pro-B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stem cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube development	ISO Inferred from Sequence Orthology more info
involved_in neural tube development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuronal stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in neuronal stem cell population maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within oligodendrocyte development	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in regulation of myelination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in smoothened signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in specification of loop of Henle identity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within telencephalon development	ISO Inferred from Sequence Orthology more info
involved_in telencephalon development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcription factor HES-5

Names: hairy and enhancer of split 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024383.1 → NP_077359.1 transcription factor HES-5

See identical proteins and their annotated locations for NP_077359.1

Status: PROVISIONAL

Source sequence(s)

D12516

UniProtKB/Swiss-Prot

Q03062

UniProtKB/TrEMBL

A6IUM9

Related

ENSRNOP00000018769.1, ENSRNOT00000018769.4

Conserved Domains (3) summary

smart00511
Location:86 → 128

ORANGE; Orange domain

cd11461
Location:18 → 76

bHLH-O_HES5; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-5 and similar proteins

NF038079
Location:117 → 159

TonB_sider_MxcH; TonB-dependent siderophore myxochelin receptor MxcH

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

170804511..170807988

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110831.2 → XP_038966759.1 transcription factor HES-5 isoform X1

Conserved Domains (2) summary

smart00511
Location:116 → 158

ORANGE; Orange domain

cd11461
Location:18 → 74

bHLH-O_HES5; basic helix-loop-helix-orange (bHLH-O) domain found in transcription factor HES-5 and similar proteins