Cgref1 cell growth regulator with EF hand domain 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cgref1provided by RGD
Official Full Name: cell growth regulator with EF hand domain 1provided by RGD
Primary source: RGD:620801
See related: EnsemblRapid:ENSRNOG00000007923 AllianceGenome:RGD:620801
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cgr11
Summary: Predicted to enable calcium ion binding activity. Involved in negative regulation of cell growth. Predicted to be located in extracellular region. Orthologous to human CGREF1 (cell growth regulator with EF-hand domain 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 111.8), Brain (RPKM 71.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (31151795..31163801)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (25431846..25443853)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (26797126..26809132)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cgr11 encodes a secretory protein involved in cell adhesion
Title: Cgr11 encodes a secretory protein involved in cell adhesion.
CGR11 appears to be a primary response gene expressed to moderate levels in functional p53 cells.
Title: Induction of cell growth regulatory genes by p53.

Submit: New GeneRIF Correction

General gene information

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Markers

AW045201 (e-PCR)
- UniSTS:164281

Cgr11 (e-PCR)
- UniSTS:261075

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell growth regulator with EF hand domain protein 1

Names: cell growth regulatory gene 11 protein; cell growth regulatory with EF-hand domain; hydrophobestin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.