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    Slc38a9 solute carrier family 38, member 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310091, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc38a9provided by RGD
    Official Full Name
    solute carrier family 38, member 9provided by RGD
    Primary source
    RGD:1311881
    See related
    EnsemblRapid:ENSRNOG00000009851 AllianceGenome:RGD:1311881
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311881
    Summary
    Predicted to enable several functions, including L-amino acid transmembrane transporter activity; arginine binding activity; and cholesterol binding activity. Predicted to be involved in carboxylic acid transport; cellular response to amino acid stimulus; and positive regulation of TORC1 signaling. Predicted to be located in late endosome and lysosome. Predicted to be part of FNIP-folliculin RagC/D GAP and Ragulator complex. Predicted to be active in lysosomal membrane. Orthologous to human SLC38A9 (solute carrier family 38 member 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 62.3), Thymus (RPKM 56.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slc38a9 in Genome Data Viewer
    Location:
    2q14
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (46024731..46102419)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (44291637..44374897)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (44512556..44592793)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene serine/arginine-rich splicing factor 3 pseudogene Neighboring gene interleukin 31 receptor A Neighboring gene DEAD-box helicase 4 Neighboring gene heterogeneous nuclear ribonucleoprotein R, pseudogene 1 Neighboring gene uncharacterized LOC120100707 Neighboring gene phospholipid phosphatase 1 Neighboring gene Mtr4 exosome RNA helicase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient. Wyant GA, et al. Cell, 2017 Oct 19. PMID 29053970, Free PMC Article
    2. Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling. Jung JW, et al. Cell Metab, 2019 Jun 4. PMID 30956113
    3. Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene. denDekker AD, et al. Cancer Res, 2012 Nov 15. PMID 22993404, Free PMC Article
    4. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Wang S, et al. Science, 2015 Jan 9. PMID 25567906, Free PMC Article
    5. SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1. Rebsamen M, et al. Nature, 2015 Mar 26. PMID 25561175, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125012

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-arginine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-arginine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables L-asparagine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-asparagine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables L-glutamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables L-glutamine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables L-leucine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables active monoatomic ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables amino acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables arginine binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cholesterol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables inorganic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables secondary active transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol sensor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sterol sensor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in L-arginine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in amino acid transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in asparagine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in asparagine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in branched-chain amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to amino acid stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glutamine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutamine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in inorganic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of TORC1 signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of FNIP-folliculin RagC/D GAP ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Ragulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Ragulator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    neutral amino acid transporter 9
    Names
    putative sodium-coupled neutral amino acid transporter 9
    sodium-coupled neutral amino acid transporter 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035251.1 → NP_001030328.1  neutral amino acid transporter 9

      See identical proteins and their annotated locations for NP_001030328.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105869
      UniProtKB/Swiss-Prot
      Q3B8Q3, Q561Z8, R9PXU2
      UniProtKB/TrEMBL
      A6I5P6, H9BFG3
      Conserved Domains (1) summary
      cl00456
      Location:114 → 555
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      46024731..46102419
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281731.1 → XP_063137801.1  neutral amino acid transporter 9 isoform X1

      UniProtKB/Swiss-Prot
      Q3B8Q3, Q561Z8, R9PXU2
      UniProtKB/TrEMBL
      H9BFG3

    2. XM_006231929.5 → XP_006231991.1  neutral amino acid transporter 9 isoform X1

      See identical proteins and their annotated locations for XP_006231991.1

      UniProtKB/Swiss-Prot
      Q3B8Q3, Q561Z8, R9PXU2
      UniProtKB/TrEMBL
      A6I5P6, H9BFG3
      Conserved Domains (1) summary
      cl00456
      Location:114 → 555
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. XM_006231930.5 → XP_006231992.1  neutral amino acid transporter 9 isoform X1

      See identical proteins and their annotated locations for XP_006231992.1

      UniProtKB/Swiss-Prot
      Q3B8Q3, Q561Z8, R9PXU2
      UniProtKB/TrEMBL
      A6I5P6, H9BFG3
      Related
      ENSRNOP00000099743.1, ENSRNOT00000132035.1
      Conserved Domains (1) summary
      cl00456
      Location:114 → 555
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. XM_006231931.5 → XP_006231993.1  neutral amino acid transporter 9 isoform X1

      See identical proteins and their annotated locations for XP_006231993.1

      UniProtKB/Swiss-Prot
      Q3B8Q3, Q561Z8, R9PXU2
      UniProtKB/TrEMBL
      A6I5P6, H9BFG3
      Conserved Domains (1) summary
      cl00456
      Location:114 → 555
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    5. XM_063281732.1 → XP_063137802.1  neutral amino acid transporter 9 isoform X3

    6. XM_063281733.1 → XP_063137803.1  neutral amino acid transporter 9 isoform X3

    7. XM_006231937.5 → XP_006231999.1  neutral amino acid transporter 9 isoform X3

      See identical proteins and their annotated locations for XP_006231999.1

      UniProtKB/TrEMBL
      A6I5P7
      Conserved Domains (2) summary
      COG0814
      Location:53 → 497
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:52 → 493
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    8. XM_006231934.4 → XP_006231996.1  neutral amino acid transporter 9 isoform X2

      UniProtKB/TrEMBL
      A6I5P7
      Related
      ENSRNOP00000013218.7, ENSRNOT00000013218.8
      Conserved Domains (2) summary
      COG0814
      Location:83 → 527
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:82 → 523
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    9. XM_063281735.1 → XP_063137805.1  neutral amino acid transporter 9 isoform X3

    10. XM_063281734.1 → XP_063137804.1  neutral amino acid transporter 9 isoform X3

    11. XM_006231936.4 → XP_006231998.1  neutral amino acid transporter 9 isoform X3

      See identical proteins and their annotated locations for XP_006231998.1

      UniProtKB/TrEMBL
      A6I5P7
      Conserved Domains (2) summary
      COG0814
      Location:53 → 497
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:52 → 493
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    12. XM_006231939.5 → XP_006232001.1  neutral amino acid transporter 9 isoform X3

      See identical proteins and their annotated locations for XP_006232001.1

      UniProtKB/TrEMBL
      A6I5P7
      Conserved Domains (2) summary
      COG0814
      Location:53 → 497
      SdaC; Amino acid permease [Amino acid transport and metabolism]
      cl00456
      Location:52 → 493
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    13. XM_006231932.4 → XP_006231994.1  neutral amino acid transporter 9 isoform X1

      See identical proteins and their annotated locations for XP_006231994.1

      UniProtKB/Swiss-Prot
      Q3B8Q3, Q561Z8, R9PXU2
      UniProtKB/TrEMBL
      A6I5P6, H9BFG3
      Conserved Domains (1) summary
      cl00456
      Location:114 → 555
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3B8Q3.1 GenPept UniProtKB/Swiss-Prot:Q3B8Q3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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