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    Kbtbd2 kelch repeat and BTB domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312372, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kbtbd2provided by RGD
    Official Full Name
    kelch repeat and BTB domain containing 2provided by RGD
    Primary source
    RGD:1310317
    See related
    EnsemblRapid:ENSRNOG00000013809 AllianceGenome:RGD:1310317
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; protein K48-linked ubiquitination; and regulation of cellular response to insulin stimulus. Predicted to act upstream of or within with a positive effect on several processes, including glucose metabolic process; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and response to insulin. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human KBTBD2 (kelch repeat and BTB domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 136.4), Lung (RPKM 130.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kbtbd2 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (87358133..87380399, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (86027947..86050266, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (87088759..87111576, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene AVL9 cell migration associated Neighboring gene FKBP prolyl isomerase 9 Neighboring gene 5'-nucleotidase, cytosolic IIIA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice. Zhang Z, et al. Proc Natl Acad Sci U S A, 2016 Oct 18. PMID 27708159, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within_positive_effect gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within_positive_effect glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within_positive_effect lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within_positive_effect phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within_positive_effect response to insulin ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch repeat and BTB domain-containing protein 2
    Names
    kelch repeat and BTB (POZ) domain containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107861.1 → NP_001101331.1  kelch repeat and BTB domain-containing protein 2

      See identical proteins and their annotated locations for NP_001101331.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474011
      UniProtKB/TrEMBL
      A6K117, D3ZVS6
      Related
      ENSRNOP00000018442.5, ENSRNOT00000018442.7
      Conserved Domains (4) summary
      PHA03098
      Location:23 → 516
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:374 → 415
      Kelch; KELCH repeat [structural motif]
      cd18270
      Location:5 → 137
      BTB_POZ_KBTBD2_BKLHD1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2)
      cd18479
      Location:128 → 223
      BACK_KBTBD2; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      87358133..87380399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762892.4 → XP_008761114.1  kelch repeat and BTB domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008761114.1

      UniProtKB/TrEMBL
      A6K117, D3ZVS6
      Conserved Domains (4) summary
      PHA03098
      Location:23 → 516
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:374 → 415
      Kelch; KELCH repeat [structural motif]
      cd18270
      Location:5 → 137
      BTB_POZ_KBTBD2_BKLHD1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2)
      cd18479
      Location:128 → 223
      BACK_KBTBD2; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2)

    2. XM_006236548.5 → XP_006236610.1  kelch repeat and BTB domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006236610.1

      UniProtKB/TrEMBL
      A6K117, D3ZVS6
      Conserved Domains (4) summary
      PHA03098
      Location:23 → 516
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:374 → 415
      Kelch; KELCH repeat [structural motif]
      cd18270
      Location:5 → 137
      BTB_POZ_KBTBD2_BKLHD1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2)
      cd18479
      Location:128 → 223
      BACK_KBTBD2; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2)

    3. XM_008762893.4 → XP_008761115.1  kelch repeat and BTB domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008761115.1

      UniProtKB/TrEMBL
      A6K117, D3ZVS6
      Conserved Domains (4) summary
      PHA03098
      Location:23 → 516
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:374 → 415
      Kelch; KELCH repeat [structural motif]
      cd18270
      Location:5 → 137
      BTB_POZ_KBTBD2_BKLHD1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2)
      cd18479
      Location:128 → 223
      BACK_KBTBD2; BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2)

    4. XM_063286038.1 → XP_063142108.1  kelch repeat and BTB domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6K117, D3ZVS6

    5. XM_063286037.1 → XP_063142107.1  kelch repeat and BTB domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A6K117, D3ZVS6
    Nucleotide Protein Strain
    Heading Accession and Version

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