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    Dctd dCMP deaminase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290741, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dctdprovided by RGD
    Official Full Name
    dCMP deaminaseprovided by RGD
    Primary source
    RGD:1359671
    See related
    EnsemblRapid:ENSRNOG00000013215 AllianceGenome:RGD:1359671
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable dCMP deaminase activity; deoxyribonucleoside 5'-monophosphate N-glycosidase activity; and identical protein binding activity. Predicted to be involved in cytidine deamination and nucleoside salvage. Predicted to be active in cytoplasm. Orthologous to human DCTD (dCMP deaminase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 61.9), Adrenal (RPKM 52.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dctd in Genome Data Viewer
    Location:
    16q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (50799699..50831398, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (44066952..44098654, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (47177144..47222850, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552563 Neighboring gene uncharacterized LOC134482500 Neighboring gene macrophage migration inhibitory factor, pseudogene 4 Neighboring gene uncharacterized LOC120097446 Neighboring gene ribosomal protein S15a, pseudogene 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Properties of an affinity-column-purified human deoxycytidylate deaminase. Maley GF, et al. Biochim Biophys Acta, 1993 Mar 5. PMID 8448179
    2. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
    3. Toward an understanding of the protein interaction network of the human liver. Wang J, et al. Mol Syst Biol, 2011 Oct 11. PMID 21988832, Free PMC Article
    4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 5-hydroxymethyl-dUMP N-hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5-hydroxymethyl-dUMP N-hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 5-hydroxymethyl-dUMP N-hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dCMP deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dCMP deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytidine deamination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dTMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dUMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleoside salvage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleoside salvage ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    deoxycytidylate deaminase
    NP_001013904.2
    NP_001154984.1
    XP_038950302.1
    XP_038950304.1
    XP_063131299.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013882.2 → NP_001013904.2  deoxycytidylate deaminase isoform 1

      See identical proteins and their annotated locations for NP_001013904.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).
      Source sequence(s)
      BC087138, EV776012
      UniProtKB/TrEMBL
      A0A0A0MXX3, A6JPJ8
      Related
      ENSRNOP00000017670.5, ENSRNOT00000017670.10
      Conserved Domains (1) summary
      cd01286
      Location:23 → 144
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

    2. NM_001161512.1 → NP_001154984.1  deoxycytidylate deaminase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, and lacks an alternate exon in the 3' coding region that causes a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      BC087138, BP504069, DY317307
      UniProtKB/TrEMBL
      D3ZXS5
      Related
      ENSRNOP00000056214.3, ENSRNOT00000059459.6
      Conserved Domains (1) summary
      cd01286
      Location:23 → 126
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      50799699..50831398 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094376.1 → XP_038950304.1  deoxycytidylate deaminase isoform X3

      UniProtKB/TrEMBL
      A0A8I6ATK1
      Conserved Domains (1) summary
      cl00269
      Location:23 → 87
      cytidine_deaminase-like; Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members ...

    2. XM_039094374.1 → XP_038950302.1  deoxycytidylate deaminase isoform X1

      UniProtKB/TrEMBL
      A0A0A0MXX3, A6JPJ8
      Conserved Domains (1) summary
      cd01286
      Location:23 → 144
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

    3. XM_063275229.1 → XP_063131299.1  deoxycytidylate deaminase isoform X2

      UniProtKB/TrEMBL
      D3ZXS5

    RNA

    1. XR_010058286.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M9G0.1 GenPept UniProtKB/Swiss-Prot:Q5M9G0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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