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    Mapda N6-Methyl-AMP deaminase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311352, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Mapdaprovided by RGD
    Official Full Name
    N6-Methyl-AMP deaminaseprovided by RGD
    Primary source
    RGD:1359517
    See related
    EnsemblRapid:ENSRNOG00000012166 AllianceGenome:RGD:1359517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Adal
    Summary
    Predicted to enable several functions, including deaminase activity; structural molecule activity; and zinc ion binding activity. Predicted to be involved in nucleotide metabolic process and viral process. Predicted to act upstream of or within response to alcohol. Orthologous to human MAPDA (N6-Methyl-AMP deaminase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 34.3), Thymus (RPKM 34.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mapda in Genome Data Viewer
    Location:
    3q35
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (128555604..128583809)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (108101857..108119557)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (113091696..113109841)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene transglutaminase 5 Neighboring gene transglutaminase 7 Neighboring gene leucine carboxyl methyltransferase 2 Neighboring gene zinc finger and SCAN domain containing 29, pseudogene 1 Neighboring gene tubulin gamma complex component 4 Neighboring gene tumor protein p53 binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates. Murakami E, et al. J Med Chem, 2011 Aug 25. PMID 21755941
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109297

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to alcohol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in viral process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenosine deaminase-like protein
    Names
    adenosine deaminase-like
    NP_001014069.2
    XP_008760388.1
    XP_008760389.1
    XP_008760391.1
    XP_017447223.1
    XP_017447225.1
    XP_038960881.1
    XP_038960882.1
    XP_038960883.1
    XP_063139784.1
    XP_063139785.1
    XP_063139786.1
    XP_063139787.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014047.2 → NP_001014069.2  adenosine deaminase-like protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      Related
      ENSRNOP00000111630.1, ENSRNOT00000159363.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      128555604..128583809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762166.4 → XP_008760388.1  adenosine deaminase-like protein isoform X1

      Conserved Domains (1) summary
      cd00443
      Location:17 → 344
      ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

    2. XM_017591734.3 → XP_017447223.1  adenosine deaminase-like protein isoform X1

      Conserved Domains (1) summary
      cd00443
      Location:17 → 344
      ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

    3. XM_063283717.1 → XP_063139787.1  adenosine deaminase-like protein isoform X6

    4. XM_008762169.4 → XP_008760391.1  adenosine deaminase-like protein isoform X3

      Conserved Domains (1) summary
      cd00443
      Location:29 → 310
      ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

    5. XM_039104955.2 → XP_038960883.1  adenosine deaminase-like protein isoform X3

      Conserved Domains (1) summary
      cd00443
      Location:29 → 310
      ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

    6. XM_039104954.2 → XP_038960882.1  adenosine deaminase-like protein isoform X1

      Conserved Domains (1) summary
      cd00443
      Location:17 → 344
      ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

    7. XM_063283714.1 → XP_063139784.1  adenosine deaminase-like protein isoform X1

    8. XM_039104953.2 → XP_038960881.1  adenosine deaminase-like protein isoform X1

      Conserved Domains (1) summary
      cd00443
      Location:17 → 344
      ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

    9. XM_008762167.4 → XP_008760389.1  adenosine deaminase-like protein isoform X4

      UniProtKB/TrEMBL
      A0A8J8YAK5
      Conserved Domains (1) summary
      cd00443
      Location:1 → 230
      ADA_AMPD; Adenosine/AMP deaminase. Adenosine deaminases (ADAs) are present in pro- and eukaryotic organisms and catalyze the zinc dependent irreversible deamination of adenosine nucleosides to inosine nucleosides and ammonia. The eukaryotic AMP deaminase ...

    10. XM_017591736.3 → XP_017447225.1  adenosine deaminase-like protein isoform X5

      UniProtKB/TrEMBL
      A0A8J8YAK5, F1LRK5, Q5FVI8
      Conserved Domains (1) summary
      cl00281
      Location:3 → 201
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    11. XM_063283716.1 → XP_063139786.1  adenosine deaminase-like protein isoform X4

      UniProtKB/TrEMBL
      A0A8J8YAK5

    12. XM_063283715.1 → XP_063139785.1  adenosine deaminase-like protein isoform X2

    RNA

    1. XR_010064618.1 RNA Sequence

    2. XR_010064619.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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