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    Fbxl5 F-box and leucine-rich repeat protein 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305424, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Fbxl5provided by RGD
    Official Full Name
    F-box and leucine-rich repeat protein 5provided by RGD
    Primary source
    RGD:1306887
    See related
    EnsemblRapid:ENSRNOG00000005261 AllianceGenome:RGD:1306887
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable iron ion binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; intracellular iron ion homeostasis; and protein ubiquitination. Predicted to act upstream of or within multicellular organismal-level iron ion homeostasis and positive regulation of protein catabolic process. Predicted to be located in perinuclear region of cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXL5 (F-box and leucine rich repeat protein 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 368.6), Brain (RPKM 323.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbxl5 in Genome Data Viewer
    Location:
    14q21
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (71517452..71559850)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (67305109..67347383)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (71852649..71891143)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene bone marrow stromal cell antigen 1 Neighboring gene uncharacterized LOC108352765 Neighboring gene cytochrome c, somatic pseudogene Neighboring gene coiled-coil and C2 domain containing 2A Neighboring gene C1q and TNF related 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FBXL5 interacts with p150Glued and regulates its ubiquitination. Zhang N, et al. Biochem Biophys Res Commun, 2007 Jul 20. PMID 17532294
    2. Control of iron homeostasis by an iron-regulated ubiquitin ligase. Vashisht AA, et al. Science, 2009 Oct 30. PMID 19762596, Free PMC Article
    3. An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis. Salahudeen AA, et al. Science, 2009 Oct 30. PMID 19762597, Free PMC Article
    4. The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo. Moroishi T, et al. Cell Metab, 2011 Sep 7. PMID 21907140
    5. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, et al. Biochim Biophys Acta, 2015 May. PMID 25661197

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401432.1 → NP_001388361.1  F-box/LRR-repeat protein 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A0G2JTC9
      Related
      ENSRNOP00000110832.1, ENSRNOT00000172538.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      71517452..71559850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039091944.2 → XP_038947872.1  F-box/LRR-repeat protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZSP0, A0A8I6AK75
      Related
      ENSRNOP00000101249.1, ENSRNOT00000126192.1
      Conserved Domains (4) summary
      cd09293
      Location:324 → 388
      AMN1; Antagonist of mitotic exit network protein 1
      cd12109
      Location:13 → 144
      Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
      sd00034
      Location:342 → 368
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:189 → 233
      F-box-like

    2. XM_063273139.1 → XP_063129209.1  F-box/LRR-repeat protein 5 isoform X2

      Related
      ENSRNOP00000093757.2, ENSRNOT00000101227.2

    3. XM_063273140.1 → XP_063129210.1  F-box/LRR-repeat protein 5 isoform X5

    4. XM_039091946.2 → XP_038947874.1  F-box/LRR-repeat protein 5 isoform X4

      Conserved Domains (2) summary
      cd12109
      Location:7 → 160
      Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
      pfam12937
      Location:205 → 249
      F-box-like

    5. XM_017599194.3 → XP_017454683.1  F-box/LRR-repeat protein 5 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZSP0

    6. XM_017599195.3 → XP_017454684.1  F-box/LRR-repeat protein 5 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZSP0

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107222.1: Suppressed sequence

      Description
      NM_001107222.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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