Pi4k2a phosphatidylinositol 4-kinase type 2 alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pi4k2aprovided by RGD
Official Full Name: phosphatidylinositol 4-kinase type 2 alphaprovided by RGD
Primary source: RGD:620485
See related: EnsemblRapid:ENSRNOG00000014675 AllianceGenome:RGD:620485
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pi4KII
Summary: Enables 1-phosphatidylinositol 4-kinase activity. Involved in basophil degranulation. Located in several cellular components, including cytoplasmic vesicle membrane; growing cell tip; and perikaryon. Part of protein-containing complex. Orthologous to human PI4K2A (phosphatidylinositol 4-kinase type 2 alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 52.1), Adrenal (RPKM 49.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q54

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (250850440..250878399)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (240902804..240929234)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (261337594..261362509)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GSK-3beta regulates the synaptic expression of NMDA receptors via phosphorylation of phosphatidylinositol 4 kinase type IIalpha.
Title: GSK-3β regulates the synaptic expression of NMDA receptors via phosphorylation of phosphatidylinositol 4 kinase type IIα.
PI4KIIalpha plays a role in the exocytotic process downstream of Ca(2+) signaling in antigen-mediated mast cell activation.
Title: The role of phosphatidylinositol 4-kinase type IIalpha in degranulation of RBL-2H3 cells.
This enzyme is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells
Title: Phosphatidylinositol 4-OH kinase is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells.
PI4KIIalpha is present on adaptor protein (AP) -3 organelles where it regulates AP-3 function
Title: Phosphatidylinositol-4-kinase type II alpha is a component of adaptor protein-3-derived vesicles.
defined the minimal catalytic domain and identified conserved amino acid residues required for catalysis
Title: Analysis of the catalytic domain of phosphatidylinositol 4-kinase type II.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol 4-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol 4-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol 4-kinase activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol 4-kinase activity	ISO Inferred from Sequence Orthology more info
enables AP-3 adaptor complex binding	IEA Inferred from Electronic Annotation more info
enables AP-3 adaptor complex binding	ISO Inferred from Sequence Orthology more info
enables AP-3 adaptor complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in basophil degranulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of BLOC-1 complex	IEA Inferred from Electronic Annotation more info
part_of BLOC-1 complex	ISO Inferred from Sequence Orthology more info
part_of BLOC-1 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in exocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growing cell tip	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in presynaptic active zone	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphatidylinositol 4-kinase type 2-alpha

Names: 55 kDa type II phosphatidylinositol 4-kinase; phosphatidylinositol 4-kinase type II; phosphatidylinositol 4-kinase type II-alpha

NP_446187.1

EC 2.7.1.67

XP_038963964.1

EC 2.7.1.67

XP_038964019.1

EC 2.7.1.67

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053735.2 → NP_446187.1 phosphatidylinositol 4-kinase type 2-alpha

See identical proteins and their annotated locations for NP_446187.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q99M64

UniProtKB/TrEMBL

A6JHA5

Related

ENSRNOP00000094624.2, ENSRNOT00000095169.2

Conserved Domains (1) summary

pfam00454
Location:132 → 428

PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

250850440..250878399

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039108036.2 → XP_038963964.1 phosphatidylinositol 4-kinase type 2-alpha isoform X1

UniProtKB/TrEMBL

A0A8I6GL94

Conserved Domains (1) summary

pfam00454
Location:132 → 426

PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase
XM_039108091.2 → XP_038964019.1 phosphatidylinositol 4-kinase type 2-alpha isoform X2

UniProtKB/Swiss-Prot

Q99M64

UniProtKB/TrEMBL

A6JHA5

Conserved Domains (1) summary

pfam00454
Location:132 → 428

PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase