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    Cela3b chymotrypsin like elastase 3B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298567, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cela3bprovided by RGD
    Official Full Name
    chymotrypsin like elastase 3Bprovided by RGD
    Primary source
    RGD:1307819
    See related
    EnsemblRapid:ENSRNOG00000021619 AllianceGenome:RGD:1307819
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ela3b
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Orthologous to several human genes including CELA3B (chymotrypsin like elastase 3B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 2387.4) and Liver (RPKM 663.5) See more
    Orthologs
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    Genomic context

    See Cela3b in Genome Data Viewer
    Location:
    5q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (154912170..154920333, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (149628773..149636937, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (155763877..155772048, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene Wnt family member 4 Neighboring gene cell division cycle 42 Neighboring gene RIKEN cDNA 1700013G24 gene like Neighboring gene heparan sulfate proteoglycan 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    chymotrypsin-like elastase family member 3B
    Names
    chymotrypsin-like elastase family, member 3B
    elastase 3B, pancreatic
    NP_001100162.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106692.1NP_001100162.1  chymotrypsin-like elastase family member 3B precursor

      See identical proteins and their annotated locations for NP_001100162.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A6ITD6, D3ZFG3
      Related
      ENSRNOP00000036674.5, ENSRNOT00000036788.6
      Conserved Domains (2) summary
      smart00020
      Location:27262
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:28265
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      154912170..154920333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)