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    Aasdhppt aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300328, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Aasdhpptprovided by RGD
    Official Full Name
    aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferaseprovided by RGD
    Primary source
    RGD:1311360
    See related
    EnsemblRapid:ENSRNOG00000005795 AllianceGenome:RGD:1311360
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable holo-[acyl-carrier-protein] synthase activity and magnesium ion binding activity. Predicted to be involved in lysine biosynthetic process via aminoadipic acid and protein maturation. Predicted to act upstream of with a positive effect on 10-formyltetrahydrofolate catabolic process. Predicted to be active in cytosol. Orthologous to human AASDHPPT (aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 313.8), Liver (RPKM 309.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Aasdhppt in Genome Data Viewer
    Location:
    8q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (9731592..9748934, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (1453226..1463990, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (1432757..1450175, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ST13, Hsp70 interacting protein, pseudogene 8 Neighboring gene MLV-related proviral Env polyprotein-like, pseudogene 5 Neighboring gene kelch repeat and BTB domain containing 3 Neighboring gene zinc finger protein 431 like, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mechanism and substrate recognition of human holo ACP synthase. Bunkoczi G, et al. Chem Biol, 2007 Nov. PMID 18022563, Free PMC Article
    2. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables holo-[acyl-carrier-protein] synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables holo-[acyl-carrier-protein] synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables holo-[acyl-carrier-protein] synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables holo-[acyl-carrier-protein] synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in 10-formyltetrahydrofolate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_positive_effect 10-formyltetrahydrofolate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lysine biosynthetic process via aminoadipic acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
    Names
    4'-phosphopantetheinyl transferase
    AASD-PPT
    alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase
    NP_001100268.2
    XP_063121112.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106798.2 → NP_001100268.2  L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

      See identical proteins and their annotated locations for NP_001100268.2

      Status: PROVISIONAL

      Source sequence(s)
      BC166800
      UniProtKB/Swiss-Prot
      B2RYJ4
      UniProtKB/TrEMBL
      A0A8L2Q484
      Related
      ENSRNOP00000008062.6, ENSRNOT00000008062.9
      Conserved Domains (1) summary
      COG2091
      Location:30 → 205
      Sfp; Phosphopantetheinyl transferase [Coenzyme transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      9731592..9748934 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265042.1 → XP_063121112.1  L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RYJ4.1 GenPept UniProtKB/Swiss-Prot:B2RYJ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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