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    Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361845, updated on 27-Nov-2024

    Summary

    Official Symbol
    Eif4ebp2provided by RGD
    Official Full Name
    eukaryotic translation initiation factor 4E binding protein 2provided by RGD
    Primary source
    RGD:1310824
    See related
    EnsemblRapid:ENSRNOG00000070935 AllianceGenome:RGD:1310824
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable eukaryotic initiation factor 4E binding activity and translation repressor activity. Predicted to be involved in several processes, including memory; negative regulation of translational initiation; and social behavior. Predicted to act upstream of or within TOR signaling and insulin receptor signaling pathway. Is active in postsynapse. Orthologous to human EIF4EBP2 (eukaryotic translation initiation factor 4E binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 141.8), Thymus (RPKM 95.4) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Eif4ebp2 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (29922260..29942922, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (29379444..29400110, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (31055292..31072469, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene phosphatase domain containing, paladin 1 Neighboring gene nodal growth differentiation factor Neighboring gene cysteine and glycine-rich protein 2, pseudogene 1 Neighboring gene leucine rich repeat containing 20 Neighboring gene ribosomal protein L27, pseudogene 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC124760

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables eukaryotic initiation factor 4E binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables eukaryotic initiation factor 4E binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation repressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in social behavior ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in intracellular membraneless organelle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuronal ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 4E-binding protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033069.3NP_001028241.1  eukaryotic translation initiation factor 4E-binding protein 2

      See identical proteins and their annotated locations for NP_001028241.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A0G2K113, A0A8I6A0I3, Q497A9
      Related
      ENSRNOP00000099675.1, ENSRNOT00000118903.2
      Conserved Domains (1) summary
      pfam05456
      Location:3120
      eIF_4EBP; Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      29922260..29942922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)