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    Tprn taperin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499749, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tprnprovided by RGD
    Official Full Name
    taperinprovided by RGD
    Primary source
    RGD:1562935
    See related
    EnsemblRapid:ENSRNOG00000010896 AllianceGenome:RGD:1562935
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity; protein phosphatase 1 binding activity; and protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in auditory receptor cell stereocilium organization; sensory perception of sound; and stereocilium maintenance. Predicted to be located in several cellular components, including microvillus; nucleoplasm; and stereocilium. Predicted to be active in stereocilium base. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 79. Orthologous to human TPRN (taperin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 146.9), Kidney (RPKM 95.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tprn in Genome Data Viewer
    Location:
    3p13
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (28474322..28481800)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (8076164..8083642)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (2480232..2487710)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene NADPH dependent diflavin oxidoreductase 1 Neighboring gene transmembrane protein 203 Neighboring gene SS nuclear autoantigen 1 Neighboring gene anaphase promoting complex subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Progressive hearing loss and degeneration of hair cell stereocilia in taperin gene knockout mice. Chen M, et al. Biochem Biophys Res Commun, 2016 Oct 28. PMID 27693694
    2. Targeted capture and next-generation sequencing identifies C9orf75, encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79. Rehman AU, et al. Am J Hum Genet, 2010 Mar 12. PMID 20170899, Free PMC Article
    3. Mutations in TPRN cause a progressive form of autosomal-recessive nonsyndromic hearing loss. Li Y, et al. Am J Hum Genet, 2010 Mar 12. PMID 20170898, Free PMC Article
    4. GRXCR2 Regulates Taperin Localization Critical for Stereocilia Morphology and Hearing. Liu C, et al. Cell Rep, 2018 Oct 30. PMID 30380417, Free PMC Article
    5. Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function. Zhao B, et al. Elife, 2016 Jun 8. PMID 27269051, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein phosphatase 1 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase 1 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine/threonine phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine phosphatase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in auditory receptor cell stereocilium organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within auditory receptor cell stereocilium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sensory perception of sound IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sensory perception of sound ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in stereocilium maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stereocilium maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stereocilium maintenance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microvillus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in stereocilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stereocilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in stereocilium base IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stereocilium base ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stereocilium base ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    taperin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024309.2 → NP_001019480.2  taperin

      See identical proteins and their annotated locations for NP_001019480.2

      Status: VALIDATED

      Source sequence(s)
      BC083928, JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q5XHX2
      Related
      ENSRNOP00000014489.5, ENSRNOT00000014489.7
      Conserved Domains (3) summary
      PHA03247
      Location:103 → 461
      PHA03247; large tegument protein UL36; Provisional
      pfam13914
      Location:507 → 645
      Phostensin; Phostensin PP1-binding and SH3-binding region
      pfam13916
      Location:8 → 89
      Phostensin_N; PP1-regulatory protein, Phostensin N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      28474322..28481800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XHX2.2 GenPept UniProtKB/Swiss-Prot:Q5XHX2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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