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    Eps15l1 epidermal growth factor receptor pathway substrate 15-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361120, updated on 2-Nov-2024

    Summary

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    Symbol
    Eps15l1provided by RGD
    Full Name
    epidermal growth factor receptor pathway substrate 15-like 1provided by RGD
    Primary source
    RGD:1565708
    See related
    EnsemblRapid:ENSRNOG00000013502 AllianceGenome:RGD:1565708
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in endosomal transport and synaptic vesicle endocytosis. Predicted to be part of clathrin coat of coated pit. Predicted to be active in cytoplasm; plasma membrane; and presynapse. Orthologous to human EPS15L1 (epidermal growth factor receptor pathway substrate 15 like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 140.8), Adrenal (RPKM 113.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eps15l1 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (17460330..17573824)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (17426345..17501677)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (19127635..19202991)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 19 open reading frame 44 Neighboring gene calcium homeostasis endoplasmic reticulum protein Neighboring gene calreticulin 3 Neighboring gene KLF transcription factor 2 Neighboring gene adaptor related protein complex 1 subunit mu 1 Neighboring gene family with sequence similarity 32, member A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Essential role of cyclin-G-associated kinase (Auxilin-2) in developing and mature mice. Lee DW, et al. Mol Biol Cell, 2008 Jul. PMID 18434600, Free PMC Article
    2. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    3. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116150

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endosomal transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of clathrin coat of coated pit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of clathrin coat of coated pit ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    epidermal growth factor receptor substrate 15-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029921.1 → NP_001025092.1  epidermal growth factor receptor substrate 15-like 1

      See identical proteins and their annotated locations for NP_001025092.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098004
      UniProtKB/TrEMBL
      A0A0G2QC53, A0A8I5ZKJ0
      Related
      ENSRNOP00000078247.2, ENSRNOT00000120186.2
      Conserved Domains (4) summary
      smart00027
      Location:268 → 364
      EH; Eps15 homology domain
      cd00052
      Location:131 → 196
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam07926
      Location:398 → 525
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cl02488
      Location:385 → 566
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      17460330..17573824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275500.1 → XP_063131570.1  epidermal growth factor receptor substrate 15-like 1 isoform X19

    2. XM_063275502.1 → XP_063131572.1  epidermal growth factor receptor substrate 15-like 1 isoform X21

    3. XM_039094619.2 → XP_038950547.1  epidermal growth factor receptor substrate 15-like 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AID0
      Conserved Domains (3) summary
      smart00027
      Location:268 → 364
      EH; Eps15 homology domain
      COG1196
      Location:385 → 566
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00052
      Location:19 → 85
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...

    4. XM_017600166.3 → XP_017455655.1  epidermal growth factor receptor substrate 15-like 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AID0, D3ZJR1, Q4QQT7
      Related
      ENSRNOP00000018960.8, ENSRNOT00000018960.9

    5. XM_017600168.3 → XP_017455657.1  epidermal growth factor receptor substrate 15-like 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I6AEE8

    6. XM_017600169.3 → XP_017455658.1  epidermal growth factor receptor substrate 15-like 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AID0

    7. XM_006252802.5 → XP_006252864.1  epidermal growth factor receptor substrate 15-like 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A726, A0A8I6AID0
      Related
      ENSRNOP00000088897.1, ENSRNOT00000104367.2
      Conserved Domains (4) summary
      smart00027
      Location:268 → 364
      EH; Eps15 homology domain
      cd00052
      Location:131 → 196
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam07926
      Location:398 → 525
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cl02488
      Location:385 → 566
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    8. XM_006252804.5 → XP_006252866.1  epidermal growth factor receptor substrate 15-like 1 isoform X4

      See identical proteins and their annotated locations for XP_006252866.1

      UniProtKB/TrEMBL
      A0A8I6AID0, A6K9P6
      Conserved Domains (4) summary
      smart00027
      Location:268 → 364
      EH; Eps15 homology domain
      cd00052
      Location:131 → 196
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam07926
      Location:398 → 525
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cl02488
      Location:385 → 566
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    9. XM_063275494.1 → XP_063131564.1  epidermal growth factor receptor substrate 15-like 1 isoform X8

      Related
      ENSRNOP00000090770.1, ENSRNOT00000116060.2

    10. XM_063275495.1 → XP_063131565.1  epidermal growth factor receptor substrate 15-like 1 isoform X9

    11. XM_017600167.3 → XP_017455656.1  epidermal growth factor receptor substrate 15-like 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZKJ0

    12. XM_063275497.1 → XP_063131567.1  epidermal growth factor receptor substrate 15-like 1 isoform X14

    13. XM_008771122.4 → XP_008769344.1  epidermal growth factor receptor substrate 15-like 1 isoform X15

      UniProtKB/TrEMBL
      A0A8I5ZKJ0
      Conserved Domains (4) summary
      smart00027
      Location:268 → 364
      EH; Eps15 homology domain
      cd00052
      Location:131 → 196
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam07926
      Location:398 → 525
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cl23720
      Location:402 → 519
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    14. XM_063275498.1 → XP_063131568.1  epidermal growth factor receptor substrate 15-like 1 isoform X16

    15. XM_017600170.3 → XP_017455659.1  epidermal growth factor receptor substrate 15-like 1 isoform X10

      UniProtKB/TrEMBL
      A0A8I6AEE8

    16. XM_017600174.3 → XP_017455663.1  epidermal growth factor receptor substrate 15-like 1 isoform X17

      UniProtKB/TrEMBL
      A0A8I6AEE8

    17. XM_039094620.2 → XP_038950548.1  epidermal growth factor receptor substrate 15-like 1 isoform X13

      UniProtKB/TrEMBL
      A0A8I6AEE8
      Conserved Domains (3) summary
      smart00027
      Location:268 → 364
      EH; Eps15 homology domain
      COG1196
      Location:385 → 566
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00052
      Location:19 → 85
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...

    18. XM_063275496.1 → XP_063131566.1  epidermal growth factor receptor substrate 15-like 1 isoform X11

    19. XM_063275499.1 → XP_063131569.1  epidermal growth factor receptor substrate 15-like 1 isoform X18

    20. XM_063275501.1 → XP_063131571.1  epidermal growth factor receptor substrate 15-like 1 isoform X20

    21. XM_017600173.3 → XP_017455662.1  epidermal growth factor receptor substrate 15-like 1 isoform X12

      UniProtKB/TrEMBL
      A0A8I6AEE8
    Nucleotide Protein Strain
    Heading Accession and Version

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