Cpq carboxypeptidase Q [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cpqprovided by RGD
Official Full Name: carboxypeptidase Qprovided by RGD
Primary source: RGD:628610
See related: EnsemblRapid:ENSRNOG00000005931 AllianceGenome:RGD:628610
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LAL; Pgcp; lal-1
Summary: Predicted to enable metallodipeptidase activity and protein homodimerization activity. Involved in proteolysis; thyroid hormone generation; and tissue regeneration. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and lysosome. Orthologous to human CPQ (carboxypeptidase Q). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 886.6), Liver (RPKM 660.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (66148973..66719189)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (64264025..64830867)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (71709174..72167413)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

lal-1 is involved in liver regeneration and its expression is finely regulated during proliferative process {Liver Annexin Like-1 (lal-1)
Title: lal-1: a differentially expressed novel gene during proliferation in liver regeneration and in hepatoma cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallodipeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallodipeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallodipeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallodipeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in peptide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in peptide catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone generation	IBA Inferred from Biological aspect of Ancestor more info
involved_in thyroid hormone generation	IDA Inferred from Direct Assay more info	PubMed
involved_in tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carboxypeptidase Q

Names: hematopoietic lineage switch 2 related protein; hls2-rp; liver annexin like-1; liver annexin-like protein 1; plasma glutamate carboxypeptidase

NP_113828.1

EC 3.4.17.-

XP_008763639.1

EC 3.4.17.-

XP_038935736.1

EC 3.4.17.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031640.1 → NP_113828.1 carboxypeptidase Q precursor

See identical proteins and their annotated locations for NP_113828.1

Status: PROVISIONAL

Source sequence(s)

AF097723

UniProtKB/TrEMBL

A0A8I6AKX5

Related

ENSRNOP00000008211.4, ENSRNOT00000008211.8

Conserved Domains (2) summary

cd03883
Location:47 → 449

M28_Pgcp_like; M28 Zn-Peptidase Plasma glutamate carboxypeptidase

cd04815
Location:130 → 256

PA_M28_2; PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions. ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

66148973..66719189

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008765417.4 → XP_008763639.1 carboxypeptidase Q isoform X1

See identical proteins and their annotated locations for XP_008763639.1

UniProtKB/Swiss-Prot

Q6IRK9, Q9JLV0, Q9Z1Y1

UniProtKB/TrEMBL

A0A8I6AKX5, A6HQY8

Conserved Domains (1) summary

cd03883
Location:42 → 449

M28_Pgcp_like; M28 Zn-Peptidase Plasma glutamate carboxypeptidase
XM_039079808.2 → XP_038935736.1 carboxypeptidase Q isoform X2

UniProtKB/TrEMBL

A0A8I6AKX5

Related

ENSRNOP00000108968.1, ENSRNOT00000159568.1

Conserved Domains (1) summary

cd03883
Location:42 → 435

M28_Pgcp_like; M28 Zn-Peptidase Plasma glutamate carboxypeptidase