Chrdl1 chordin-like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chrdl1provided by RGD
Official Full Name: chordin-like 1provided by RGD
Primary source: RGD:735215
See related: EnsemblRapid:ENSRNOG00000004330 AllianceGenome:RGD:735215
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kjr; Ng1; Neurogenesin-1
Summary: Predicted to enable BMP binding activity and transforming growth factor beta binding activity. Involved in cell fate determination and neuron differentiation. Predicted to be located in plasma membrane and synapse. Predicted to be active in extracellular region. Orthologous to human CHRDL1 (chordin like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 31.8), Muscle (RPKM 30.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq33

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (111685864..111789684, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (106889125..106992937, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (114554359..114658975, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The miR-532-3p/Chrdl1 axis regulates the proliferation and migration of amniotic fluid-derived mesenchymal stromal cells.
Title: The miR-532-3p/Chrdl1 axis regulates the proliferation and migration of amniotic fluid-derived mesenchymal stromal cells.
The current study indicates that CHRDL1 protein antagonizes BMP4 activity and induces spinal cordderived NSCs to differentiate into neurons.
Title: Chordin-like protein 1 promotes neuronal differentiation by inhibiting bone morphogenetic protein-4 in neural stem cells.
Ng1 gene could promote the proliferation of endogenous neural stem cells and protect injured neurons following spinal cord injury.
Title: [Effects of neurogenesin 1 gene on functional recovery of spinal cord injury in rats and its mechanism].
Neurogenesin-1 contributes to neuronal differentiation of neural stem cells in the adult brain
Title: A novel secretory factor, Neurogenesin-1, provides neurogenic environmental cues for neural stem cells in the adult hippocampus.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables BMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables BMP binding	IEA Inferred from Electronic Annotation more info
enables BMP binding	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta binding	IEA Inferred from Electronic Annotation more info
enables transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in AMPA glutamate receptor clustering	IEA Inferred from Electronic Annotation more info
involved_in AMPA glutamate receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic axis specification	IEA Inferred from Electronic Annotation more info
involved_in embryonic axis specification	ISO Inferred from Sequence Orthology more info
involved_in excitatory chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in excitatory chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in eye development	IEA Inferred from Electronic Annotation more info
involved_in eye development	ISO Inferred from Sequence Orthology more info
involved_in eye development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in synapse maturation	IEA Inferred from Electronic Annotation more info
involved_in synapse maturation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chordin-like protein 1

Names: kohjirin; neuralin-1; neurogenesin 1; ventroptin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199502.2 → NP_955796.2 chordin-like protein 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000021

UniProtKB/Swiss-Prot

Q76LD0

UniProtKB/TrEMBL

F1LQZ2

Conserved Domains (1) summary

cl17735
Location:184 → 247

VWC; von Willebrand factor type C domain