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    Zbtb21 zinc finger and BTB domain containing 21 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304056, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zbtb21provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 21provided by RGD
    Primary source
    RGD:1310841
    See related
    EnsemblRapid:ENSRNOG00000001623 AllianceGenome:RGD:1310841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfp295; Znf295
    Summary
    Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; POZ domain binding activity; and methyl-CpG binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ZBTB21 (zinc finger and BTB domain containing 21). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 70.6), Kidney (RPKM 52.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb21 in Genome Data Viewer
    Location:
    11q12
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (50781697..50796399, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (37312337..37327040, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (38442716..38457411, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene C2 calcium-dependent domain containing 2 Neighboring gene uncharacterized LOC134480980 Neighboring gene ribosomal protein S17, pseudogene 5 Neighboring gene leucine rich repeat containing 57, pseudogene 2 Neighboring gene fidgetin-like 2, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel human BTB/POZ domain-containing zinc finger protein ZNF295 is directly associated with ZFP161. Wang J, et al. Biochem Biophys Res Commun, 2005 Feb 11. PMID 15629158
    2. Nucleosome-interacting proteins regulated by DNA and histone methylation. Bartke T, et al. Cell, 2010 Oct 29. PMID 21029866, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables POZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyl-CpG binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 21
    Names
    zinc finger protein 295

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107105.2 → NP_001100575.2  zinc finger and BTB domain-containing protein 21 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A6IQH9, A6IQI0, D3ZVF2
      Related
      ENSRNOP00000049174.5, ENSRNOT00000041177.7
      Conserved Domains (4) summary
      sd00019
      Location:731 → 751
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:40 → 151
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:863 → 885
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:568 → 595
      zf_C2H2_6; Zinc Finger domain

    2. NM_001401434.1 → NP_001388363.1  zinc finger and BTB domain-containing protein 21 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      A0A8I5Y585
      Related
      ENSRNOP00000079938.2, ENSRNOT00000116969.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      50781697..50796399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006248169.5 → XP_006248231.1  zinc finger and BTB domain-containing protein 21 isoform X1

      See identical proteins and their annotated locations for XP_006248231.1

      UniProtKB/TrEMBL
      A0A8I5Y585
      Conserved Domains (6) summary
      sd00017
      Location:571 → 592
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:927 → 947
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:40 → 151
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:693 → 715
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:764 → 791
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:568 → 621
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    2. XM_006248174.5 → XP_006248236.1  zinc finger and BTB domain-containing protein 21 isoform X2

      See identical proteins and their annotated locations for XP_006248236.1

      UniProtKB/TrEMBL
      A0A8I5ZPL5, A6IQI0
      Conserved Domains (6) summary
      sd00017
      Location:543 → 564
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:899 → 919
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:12 → 123
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:665 → 687
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:736 → 763
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:540 → 593
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    3. XM_006248172.5 → XP_006248234.1  zinc finger and BTB domain-containing protein 21 isoform X2

      See identical proteins and their annotated locations for XP_006248234.1

      UniProtKB/TrEMBL
      A0A8I5ZPL5, A6IQI0
      Conserved Domains (6) summary
      sd00017
      Location:543 → 564
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:899 → 919
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:12 → 123
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:665 → 687
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:736 → 763
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:540 → 593
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    4. XM_039088401.2 → XP_038944329.1  zinc finger and BTB domain-containing protein 21 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y585
      Conserved Domains (6) summary
      sd00017
      Location:571 → 592
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:927 → 947
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:40 → 151
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:693 → 715
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:764 → 791
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:568 → 621
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    5. XM_039088404.2 → XP_038944332.1  zinc finger and BTB domain-containing protein 21 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZPL5, A6IQI0
      Related
      ENSRNOP00000076506.2, ENSRNOT00000102067.2
      Conserved Domains (6) summary
      sd00017
      Location:543 → 564
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:899 → 919
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:12 → 123
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:665 → 687
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:736 → 763
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:540 → 593
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    6. XM_039088400.2 → XP_038944328.1  zinc finger and BTB domain-containing protein 21 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y585
      Conserved Domains (6) summary
      sd00017
      Location:571 → 592
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:927 → 947
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:40 → 151
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:693 → 715
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:764 → 791
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:568 → 621
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    7. XM_039088405.2 → XP_038944333.1  zinc finger and BTB domain-containing protein 21 isoform X4

      Conserved Domains (4) summary
      sd00017
      Location:265 → 286
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:621 → 641
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl38908
      Location:40 → 80
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam18450
      Location:458 → 485
      zf_C2H2_6; Zinc Finger domain

    8. XM_063270576.1 → XP_063126646.1  zinc finger and BTB domain-containing protein 21 isoform X3

      UniProtKB/TrEMBL
      A6IQH9, A6IQI0, D3ZVF2

    9. XM_039088406.2 → XP_038944334.1  zinc finger and BTB domain-containing protein 21 isoform X6

      Conserved Domains (3) summary
      sd00019
      Location:253 → 273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl38908
      Location:40 → 81
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      pfam18450
      Location:90 → 117
      zf_C2H2_6; Zinc Finger domain

    10. XM_063270579.1 → XP_063126649.1  zinc finger and BTB domain-containing protein 21 isoform X6

      Related
      ENSRNOP00000103395.1, ENSRNOT00000130609.1

    11. XM_063270578.1 → XP_063126648.1  zinc finger and BTB domain-containing protein 21 isoform X5

    12. XM_063270580.1 → XP_063126650.1  zinc finger and BTB domain-containing protein 21 isoform X6

    13. XM_063270577.1 → XP_063126647.1  zinc finger and BTB domain-containing protein 21 isoform X3

      UniProtKB/TrEMBL
      A6IQH9, A6IQI0, D3ZVF2

    14. XM_039088403.2 → XP_038944331.1  zinc finger and BTB domain-containing protein 21 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y585
      Conserved Domains (6) summary
      sd00017
      Location:571 → 592
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:927 → 947
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:40 → 151
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:693 → 715
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:764 → 791
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:568 → 621
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    15. XM_006248167.3 → XP_006248229.1  zinc finger and BTB domain-containing protein 21 isoform X1

      See identical proteins and their annotated locations for XP_006248229.1

      UniProtKB/TrEMBL
      A0A8I5Y585
      Conserved Domains (6) summary
      sd00017
      Location:571 → 592
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:927 → 947
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18209
      Location:40 → 151
      BTB_POZ_ZBTB21_ZNF295; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21)
      pfam00096
      Location:693 → 715
      zf-C2H2; Zinc finger, C2H2 type
      pfam18450
      Location:764 → 791
      zf_C2H2_6; Zinc Finger domain
      cd20908
      Location:568 → 621
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    16. XM_063270575.1 → XP_063126645.1  zinc finger and BTB domain-containing protein 21 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZPL5, A6IQI0
    Nucleotide Protein Strain
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