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    Ece1 endothelin converting enzyme 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94204, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ece1provided by RGD
    Official Full Name
    endothelin converting enzyme 1provided by RGD
    Primary source
    RGD:620293
    See related
    EnsemblRapid:ENSRNOG00000014241 AllianceGenome:RGD:620293
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ece
    Summary
    Enables identical protein binding activity. Involved in several processes, including positive regulation of cardiac muscle hypertrophy; positive regulation of receptor recycling; and regulation of signal transduction. Located in early endosome; external side of plasma membrane; and secretory granule. Used to study acute kidney failure; congestive heart failure; hyperhomocysteinemia; hypertension; and pulmonary hypertension. Biomarker of acute kidney failure; congestive heart failure; hypertension; nephrotic syndrome; and renal fibrosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; essential hypertension; and hypertension. Orthologous to human ECE1 (endothelin converting enzyme 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 436.7), Lung (RPKM 390.8) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ece1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (155361031..155462723)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (150077679..150179375)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (156215469..156318652)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene alkaline phosphatase, biomineralization associated Neighboring gene uncharacterized LOC134487019 Neighboring gene U4 spliceosomal RNA Neighboring gene eukaryotic translation initiation factor 4 gamma, 3 Neighboring gene uncharacterized LOC102553758 Neighboring gene uncharacterized LOC134487020

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in axonogenesis involved in innervation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axonogenesis involved in innervation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood vessel diameter maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bradykinin catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bradykinin catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcitonin catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcitonin catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ear development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ear development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic digit morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic digit morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic heart tube development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic heart tube development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelin maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endothelin maturation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hormone catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide hormone processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptide hormone processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pharyngeal system development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within pharyngeal system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cAMP/PKA signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cardiac muscle hypertrophy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of receptor recycling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of receptor recycling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to cadmium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to muscle stretch IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in semaphorin-plexin signaling pathway involved in axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in semaphorin-plexin signaling pathway involved in axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in substance P catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in substance P catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sympathetic neuron axon guidance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sympathetic neuron axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Weibel-Palade body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Weibel-Palade body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    endothelin-converting enzyme 1
    Names
    ECE-1
    NP_446048.2
    XP_006239337.1
    XP_006239338.1
    XP_063144586.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053596.2NP_446048.2  endothelin-converting enzyme 1

      See identical proteins and their annotated locations for NP_446048.2

      Status: PROVISIONAL

      Source sequence(s)
      BC072504
      UniProtKB/TrEMBL
      A0A0G2K465, A0A8I6AMF9, A6ITF1, F7EP67, Q6IN10
      Related
      ENSRNOP00000072923.1, ENSRNOT00000077742.3
      Conserved Domains (2) summary
      cd08662
      Location:103752
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:90754
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      155361031..155462723
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288516.1XP_063144586.1  endothelin-converting enzyme 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AMF9
    2. XM_006239275.5XP_006239337.1  endothelin-converting enzyme 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AL15, A0A8I6AMF9
      Related
      ENSRNOP00000093768.1, ENSRNOT00000108805.2
      Conserved Domains (2) summary
      cd08662
      Location:118767
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:105769
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]
    3. XM_006239276.5XP_006239338.1  endothelin-converting enzyme 1 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AJE5, A0A8J8Y3G8
      Related
      ENSRNOP00000095338.2, ENSRNOT00000096331.2
      Conserved Domains (2) summary
      cd08662
      Location:84733
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
      COG3590
      Location:71735
      PepO; Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]