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    Myocd myocardin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246297, updated on 10-Dec-2024

    Summary

    Official Symbol
    Myocdprovided by RGD
    Official Full Name
    myocardinprovided by RGD
    Primary source
    RGD:631347
    See related
    EnsemblRapid:ENSRNOG00000003669 AllianceGenome:RGD:631347
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mycd
    Summary
    Predicted to enable several functions, including R-SMAD binding activity; enzyme binding activity; and transcription coactivator activity. Involved in several processes, including cardiocyte differentiation; hepatic stellate cell activation; and positive regulation of vascular associated smooth muscle cell migration. Located in cytoplasm and nucleus. Part of protein-DNA complex. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in congenital megabladder and dilated cardiomyopathy. Orthologous to human MYOCD (myocardin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 74.8), Uterus (RPKM 19.6) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Myocd in Genome Data Viewer
    Location:
    10q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (50332356..50426819, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (49833219..49928806, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (51682053..51781458, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 44 Neighboring gene uncharacterized LOC134480809 Neighboring gene uncharacterized LOC134480808 Neighboring gene uncharacterized LOC120095121 Neighboring gene uncharacterized LOC102554159 Neighboring gene mitogen activated protein kinase kinase 4 Neighboring gene THAP domain-containing protein 5-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding  
    enables R-SMAD binding  
    enables R-SMAD binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables RNA polymerase II-specific DNA-binding transcription factor binding  
    enables histone acetyltransferase binding  
    enables histone acetyltransferase binding  
    enables histone deacetylase binding  
    enables histone deacetylase binding  
    enables protein binding PubMed 
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    enables transcription coactivator activity  
    Items 1 - 25 of 101
    Process Evidence Code Pubs
    involved_in cardiac muscle cell apoptotic process  
    acts_upstream_of cardiac muscle cell apoptotic process  
    involved_in cardiac muscle cell differentiation  
    acts_upstream_of_or_within cardiac muscle cell differentiation  
    involved_in cardiac muscle cell differentiation  
    involved_in cardiac muscle cell myoblast differentiation  
    involved_in cardiac muscle cell myoblast differentiation  
    involved_in cardiac vascular smooth muscle cell differentiation PubMed 
    involved_in cardiac ventricle development  
    acts_upstream_of_or_within cardiac ventricle development  
    involved_in cell growth involved in cardiac muscle cell development PubMed 
    involved_in cellular component maintenance  
    acts_upstream_of_or_within cellular component maintenance  
    involved_in cellular response to angiotensin PubMed 
    involved_in cellular response to growth factor stimulus PubMed 
    involved_in cellular response to hypoxia PubMed 
    acts_upstream_of_or_within chromatin organization  
    involved_in digestive tract development  
    acts_upstream_of_or_within digestive tract development  
    involved_in ductus arteriosus closure  
    acts_upstream_of_or_within ductus arteriosus closure  
    acts_upstream_of_or_within heart development  
    involved_in heart development  
    involved_in hepatic stellate cell activation PubMed 
    involved_in lung alveolus development  
    acts_upstream_of_or_within lung alveolus development  
    involved_in negative regulation of amyloid-beta clearance  
    involved_in negative regulation of amyloid-beta clearance  
    involved_in negative regulation of cardiac muscle cell apoptotic process  
    acts_upstream_of_or_within negative regulation of cardiac muscle cell apoptotic process  
    involved_in negative regulation of cell adhesion molecule production  
    acts_upstream_of negative regulation of cell adhesion molecule production  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity  
    involved_in negative regulation of myotube differentiation  
    acts_upstream_of_or_within negative regulation of myotube differentiation  
    involved_in negative regulation of platelet-derived growth factor receptor-beta signaling pathway  
    involved_in negative regulation of platelet-derived growth factor receptor-beta signaling pathway  
    involved_in negative regulation of skeletal muscle cell differentiation  
    involved_in negative regulation of skeletal muscle cell differentiation  
    involved_in negative regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II  
    involved_in negative regulation of vascular associated smooth muscle cell migration  
    involved_in negative regulation of vascular associated smooth muscle cell migration  
    involved_in negative regulation of vascular associated smooth muscle cell proliferation  
    involved_in negative regulation of vascular associated smooth muscle cell proliferation  
    involved_in positive regulation of DNA-binding transcription factor activity  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of cardiac muscle cell differentiation  
    involved_in positive regulation of cardiac muscle cell differentiation  
    involved_in positive regulation of cell population proliferation  
    acts_upstream_of_or_within positive regulation of cell population proliferation  
    involved_in positive regulation of epithelial to mesenchymal transition PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of miRNA transcription  
    involved_in positive regulation of miRNA transcription  
    involved_in positive regulation of smooth muscle cell differentiation  
    involved_in positive regulation of smooth muscle cell differentiation  
    involved_in positive regulation of smooth muscle contraction  
    involved_in positive regulation of smooth muscle contraction  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway  
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway  
    involved_in positive regulation of vascular associated smooth muscle cell migration PubMed 
    involved_in regulation of cell growth by extracellular stimulus  
    acts_upstream_of_or_within regulation of cell growth by extracellular stimulus  
    involved_in regulation of myoblast differentiation  
    acts_upstream_of_or_within regulation of myoblast differentiation  
    involved_in regulation of phenotypic switching  
    involved_in regulation of phenotypic switching  
    involved_in regulation of smooth muscle cell differentiation PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II  
    involved_in response to hypoxia  
    involved_in response to hypoxia  
    involved_in response to mechanical stimulus PubMed 
    involved_in response to muscle stretch PubMed 
    involved_in smooth muscle cell differentiation  
    involved_in smooth muscle cell differentiation PubMed 
    acts_upstream_of_or_within smooth muscle cell differentiation  
    involved_in smooth muscle cell differentiation  
    acts_upstream_of transcription by RNA polymerase II  
    involved_in transcription initiation-coupled chromatin remodeling  
    involved_in transcription initiation-coupled chromatin remodeling  
    involved_in transcription initiation-coupled chromatin remodeling  
    involved_in urinary bladder development  
    acts_upstream_of_or_within urinary bladder development  
    involved_in urinary bladder development  
    involved_in uterus development  
    acts_upstream_of_or_within uterus development  
    involved_in vascular associated smooth muscle cell differentiation  
    involved_in vascular associated smooth muscle cell differentiation  
    involved_in vasculogenesis  
    acts_upstream_of_or_within vasculogenesis  
    involved_in ventricular cardiac muscle cell differentiation  
    acts_upstream_of_or_within ventricular cardiac muscle cell differentiation  
    Items 1 - 25 of 101
    Component Evidence Code Pubs
    located_in chromatin  
    located_in chromatin  
    located_in cytoplasm PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in nucleus  
    located_in nucleus  
    part_of protein-DNA complex PubMed 

    General protein information

    Preferred Names
    myocardin
    Names
    transcription factor myocardin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414232.2NP_001401161.1  myocardin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2K4C5, A0A8I5ZYX5
      Related
      ENSRNOP00000072988.1, ENSRNOT00000078675.3
    2. NM_182667.4NP_872608.1  myocardin isoform 2

      See identical proteins and their annotated locations for NP_872608.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q7M6Y4, Q8R5I7, Q8R5I8
      UniProtKB/TrEMBL
      A0A8I5ZYX5
      Related
      ENSRNOP00000054372.2, ENSRNOT00000057562.5
      Conserved Domains (2) summary
      smart00707
      Location:106131
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:383416
      SAP; SAP domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      50332356..50426819 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246583.5XP_006246645.1  myocardin isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYX5
      Conserved Domains (2) summary
      smart00707
      Location:2752
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      pfam02037
      Location:304337
      SAP; SAP domain
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