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    Gpr68 G protein-coupled receptor 68 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314386, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gpr68provided by RGD
    Official Full Name
    G protein-coupled receptor 68provided by RGD
    Primary source
    RGD:1309559
    See related
    EnsemblRapid:ENSRNOG00000046309 AllianceGenome:RGD:1309559
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in cellular response to pH. Predicted to act upstream of or within negative regulation of monocyte differentiation; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and positive regulation of osteoclast development. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A6. Orthologous to human GPR68 (G protein-coupled receptor 68). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 47.3), Spleen (RPKM 36.6) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Gpr68 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (125865205..125895674, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (120135620..120166089, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (124874151..124903949, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479467 Neighboring gene D-glutamate cyclase Neighboring gene uncharacterized LOC120103602 Neighboring gene coiled-coil domain containing 88C Neighboring gene protein phosphatase 4, regulatory subunit 3A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Markers

    General protein information

    Preferred Names
    ovarian cancer G-protein coupled receptor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108049.1NP_001101519.1  ovarian cancer G-protein coupled receptor 1

      See identical proteins and their annotated locations for NP_001101519.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473982
      UniProtKB/TrEMBL
      A6JEH9, D3ZSW1
      Related
      ENSRNOP00000091078.1, ENSRNOT00000113620.2
      Conserved Domains (1) summary
      cd15367
      Location:32307
      7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. NM_001433983.1NP_001420912.1  ovarian cancer G-protein coupled receptor 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6JEH9, D3ZSW1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      125865205..125895674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112353.2XP_038968281.1  ovarian cancer G-protein coupled receptor 1 isoform X1

      Related
      ENSRNOP00000104449.1, ENSRNOT00000153809.1
      Conserved Domains (1) summary
      cd15367
      Location:32307
      7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors
    2. XM_039112352.2XP_038968280.1  ovarian cancer G-protein coupled receptor 1 isoform X1

      UniProtKB/TrEMBL
      A6JEH9, D3ZSW1
      Related
      ENSRNOP00000080372.1, ENSRNOT00000111606.2
      Conserved Domains (1) summary
      cd15367
      Location:32307
      7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors