U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Mpp2 MAGUK p55 scaffold protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85275, updated on 27-Nov-2024

    Summary

    Official Symbol
    Mpp2provided by RGD
    Official Full Name
    MAGUK p55 scaffold protein 2provided by RGD
    Primary source
    RGD:620014
    See related
    EnsemblRapid:ENSRNOG00000059683 AllianceGenome:RGD:620014
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dlg2
    Summary
    Enables PDZ domain binding activity. A structural constituent of postsynaptic density. Involved in protein homooligomerization. Located in postsynaptic density. Is active in glutamatergic synapse. Orthologous to human MPP2 (MAGUK p55 scaffold protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 63.4), Lung (RPKM 14.4) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mpp2 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (87511638..87544710, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (87011434..87043883, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89998284..90030766, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480879 Neighboring gene Cd300 molecule-like family member G Neighboring gene pancreatic polypeptide Neighboring gene peptide YY

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural constituent of postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables structural constituent of postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in maintenance of postsynaptic density structure IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein homooligomerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in Schaffer collateral - CA1 synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendrite membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic shaft IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic shaft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    MAGUK p55 subfamily member 2
    Names
    membrane palmitoylated protein 2
    membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414214.1NP_001401143.1  MAGUK p55 subfamily member 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      D3ZAA9, G3V8T8
      Related
      ENSRNOP00000072422.2, ENSRNOT00000092150.3
    2. NM_001414222.1NP_001401151.1  MAGUK p55 subfamily member 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      D3ZAA9, G3V8T8
    3. NM_053513.2NP_445965.1  MAGUK p55 subfamily member 2

      See identical proteins and their annotated locations for NP_445965.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      D3ZAA9, G3V8T8
      Related
      ENSRNOP00000073193.3, ENSRNOT00000090456.3
      Conserved Domains (5) summary
      smart00569
      Location:1366
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12037
      Location:229287
      SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
      smart00072
      Location:359540
      GuKc; Guanylate kinase homologues
      cd00992
      Location:138216
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam02828
      Location:68119
      L27; L27 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      87511638..87544710 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270001.1XP_063126071.1  MAGUK p55 subfamily member 2 isoform X2

      UniProtKB/Swiss-Prot
      D3ZAA9, G3V8T8
    2. XM_063270002.1XP_063126072.1  MAGUK p55 subfamily member 2 isoform X2

      UniProtKB/Swiss-Prot
      D3ZAA9, G3V8T8
    3. XM_008768128.3XP_008766350.1  MAGUK p55 subfamily member 2 isoform X1

      See identical proteins and their annotated locations for XP_008766350.1

      UniProtKB/TrEMBL
      A0A8L2R7D6
      Related
      ENSRNOP00000101144.1, ENSRNOT00000161854.1
      Conserved Domains (6) summary
      smart00569
      Location:3083
      L27; domain in receptor targeting proteins Lin-2 and Lin-7
      cd12037
      Location:246304
      SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
      smart00072
      Location:376557
      GuKc; Guanylate kinase homologues
      cd00992
      Location:155233
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:366556
      Guanylate_kin; Guanylate kinase
      pfam02828
      Location:85136
      L27; L27 domain