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    Aldh4a1 aldehyde dehydrogenase 4 family, member A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 641316, updated on 27-Nov-2024

    Summary

    Official Symbol
    Aldh4a1provided by RGD
    Official Full Name
    aldehyde dehydrogenase 4 family, member A1provided by RGD
    Primary source
    RGD:1624206
    See related
    EnsemblRapid:ENSRNOG00000071265 AllianceGenome:RGD:1624206
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to be located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 708.9), Kidney (RPKM 680.4) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Aldh4a1 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (157163189..157188673)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (151880002..151905491)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (158090238..158115725)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene intermediate filament family orphan 2 Neighboring gene microRNA 6215 Neighboring gene uncharacterized LOC134479043 Neighboring gene taste 1 receptor member 2 Neighboring gene paired box 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Potential readthrough

    Included gene: Iffo2

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 1-pyrroline-5-carboxylate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 1-pyrroline-5-carboxylate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 1-pyrroline-5-carboxylate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables aldehyde dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in proline catabolic process to glutamate IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intermediate filament IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
    Names
    L-glutamate gamma-semialdehyde dehydrogenase
    P5C dehydrogenase
    aldehyde dehydrogenase family 4 member A1
    NP_001128170.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134698.1NP_001128170.1  delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

      See identical proteins and their annotated locations for NP_001128170.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168153
      UniProtKB/TrEMBL
      A6ITM7, B4F768
      Related
      ENSRNOP00000098375.1, ENSRNOT00000120749.2
      Conserved Domains (1) summary
      cd07123
      Location:31552
      ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      157163189..157188673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)