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    Pgap2 post-GPI attachment to proteins 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116675, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pgap2provided by RGD
    Official Full Name
    post-GPI attachment to proteins 2provided by RGD
    Primary source
    RGD:619744
    See related
    EnsemblRapid:ENSRNOG00000020371 AllianceGenome:RGD:619744
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Frag1
    Summary
    Involved in GPI anchor biosynthetic process and protein localization to plasma membrane. Located in Golgi membrane and endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 3. Orthologous to human PGAP2 (post-GPI attachment to proteins 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 67.1), Adrenal (RPKM 52.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pgap2 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (166003593..166030088)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (156591540..156618116)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (167309021..167335550)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ADP-ribosyltransferase 1 Neighboring gene cholinergic receptor nicotinic alpha 10 subunit Neighboring gene nucleoporin 98 and 96 precursor Neighboring gene glutathione peroxidase 4, pseudogene 1 Neighboring gene ras homolog family member G Neighboring gene ribosomal protein S29, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. FRAG1, a gene that potently activates fibroblast growth factor receptor by C-terminal fusion through chromosomal rearrangement. Lorenzi MV, et al. Proc Natl Acad Sci U S A, 1996 Aug 20. PMID 8799135, Free PMC Article
    2. PGAP2 is essential for correct processing and stable expression of GPI-anchored proteins. Tashima Y, et al. Mol Biol Cell, 2006 Mar. PMID 16407401, Free PMC Article
    3. Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain. Hirata T, et al. Nat Commun, 2018 Jan 26. PMID 29374258, Free PMC Article
    4. Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. Ishii H, et al. Proc Natl Acad Sci U S A, 2005 Jul 5. PMID 15983387, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    post-GPI attachment to proteins factor 2
    Names
    FGF receptor-activating protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053895.2 → NP_446347.2  post-GPI attachment to proteins factor 2

      See identical proteins and their annotated locations for NP_446347.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I724
      Related
      ENSRNOP00000068251.3, ENSRNOT00000076894.3
      Conserved Domains (1) summary
      pfam10277
      Location:18 → 237
      Frag1; Frag1/DRAM/Sfk1 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      166003593..166030088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111279.2 → XP_038967207.1  post-GPI attachment to proteins factor 2 isoform X1

      Conserved Domains (1) summary
      pfam10277
      Location:102 → 253
      Frag1; Frag1/DRAM/Sfk1 family

    2. XM_063265385.1 → XP_063121455.1  post-GPI attachment to proteins factor 2 isoform X8

      UniProtKB/TrEMBL
      A0A8L2QZ37

    3. XM_063265587.1 → XP_063121657.1  post-GPI attachment to proteins factor 2 isoform X13

      UniProtKB/TrEMBL
      A6I724

    4. XM_017588671.3 → XP_017444160.1  post-GPI attachment to proteins factor 2 isoform X1

      Conserved Domains (1) summary
      pfam10277
      Location:102 → 253
      Frag1; Frag1/DRAM/Sfk1 family

    5. XM_063265073.1 → XP_063121143.1  post-GPI attachment to proteins factor 2 isoform X1

    6. XM_063265255.1 → XP_063121325.1  post-GPI attachment to proteins factor 2 isoform X6

    7. XM_063265142.1 → XP_063121212.1  post-GPI attachment to proteins factor 2 isoform X2

    8. XM_063265457.1 → XP_063121527.1  post-GPI attachment to proteins factor 2 isoform X10

    9. XM_063265336.1 → XP_063121406.1  post-GPI attachment to proteins factor 2 isoform X8

      UniProtKB/TrEMBL
      A0A8L2QZ37
      Related
      ENSRNOP00000052110.6, ENSRNOT00000055235.7

    10. XM_063265289.1 → XP_063121359.1  post-GPI attachment to proteins factor 2 isoform X7

    11. XM_006229837.5 → XP_006229899.1  post-GPI attachment to proteins factor 2 isoform X11

      See identical proteins and their annotated locations for XP_006229899.1

      UniProtKB/Swiss-Prot
      P70561, Q2ABP3
      Conserved Domains (1) summary
      pfam10277
      Location:18 → 241
      Frag1; Frag1/DRAM/Sfk1 family

    12. XM_006229825.5 → XP_006229887.1  post-GPI attachment to proteins factor 2 isoform X1

      Conserved Domains (1) summary
      pfam10277
      Location:102 → 253
      Frag1; Frag1/DRAM/Sfk1 family

    13. XM_006229834.5 → XP_006229896.1  post-GPI attachment to proteins factor 2 isoform X8

      UniProtKB/TrEMBL
      A0A8L2QZ37
      Conserved Domains (1) summary
      pfam10277
      Location:18 → 180
      Frag1; Frag1/DRAM/Sfk1 family

    14. XM_063265171.1 → XP_063121241.1  post-GPI attachment to proteins factor 2 isoform X3

      Related
      ENSRNOP00000101049.1, ENSRNOT00000172029.1

    15. XM_063265198.1 → XP_063121268.1  post-GPI attachment to proteins factor 2 isoform X4

    16. XM_039111474.2 → XP_038967402.1  post-GPI attachment to proteins factor 2 isoform X9

      Related
      ENSRNOP00000105018.1, ENSRNOT00000140692.1
      Conserved Domains (1) summary
      pfam10277
      Location:27 → 178
      Frag1; Frag1/DRAM/Sfk1 family

    17. XM_063265230.1 → XP_063121300.1  post-GPI attachment to proteins factor 2 isoform X5

    18. XM_063265556.1 → XP_063121626.1  post-GPI attachment to proteins factor 2 isoform X12

      UniProtKB/TrEMBL
      D4ACY7

    19. XM_063265623.1 → XP_063121693.1  post-GPI attachment to proteins factor 2 isoform X14

    20. XM_006229835.5 → XP_006229897.1  post-GPI attachment to proteins factor 2 isoform X9

      See identical proteins and their annotated locations for XP_006229897.1

      Conserved Domains (1) summary
      pfam10277
      Location:27 → 178
      Frag1; Frag1/DRAM/Sfk1 family

    21. XM_063265669.1 → XP_063121739.1  post-GPI attachment to proteins factor 2 isoform X12

      UniProtKB/TrEMBL
      D4ACY7

    22. XM_063265703.1 → XP_063121773.1  post-GPI attachment to proteins factor 2 isoform X15

    23. XM_063265742.1 → XP_063121812.1  post-GPI attachment to proteins factor 2 isoform X16

      UniProtKB/TrEMBL
      A6I731
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2ABP3.1 GenPept UniProtKB/Swiss-Prot:Q2ABP3

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